SU-E-T-204: A Prototype of Dose-Guided Radiation Therapy
Qiang Ren1,2,3,4, Gui Li1,2,3,4, Yu Wang1,2,3,4
1Institute of Nuclear Energy Safety Technology, Chinese Academy of Sciences, Hefei, Anhui, China.
Medical Physics
|May 19, 2017
Summary
A new prototype enables dose-guided radiation therapy (DGRT) by adjusting treatment plans based on past errors. This technology makes clinical DGRT feasible for improved patient outcomes.
Area of Science:
- Medical Physics
- Radiation Oncology
- Computational Imaging
Background:
- Advancements in dosimetric devices and dose reconstruction algorithms enable dose-guided radiation therapy (DGRT).
- Clinical implementation of DGRT requires a functional prototype system.
Purpose of the Study:
- To develop a prototype system for dose-guided radiation therapy (DGRT).
- To enable clinical implementation of DGRT through a functional prototype.
Main Methods:
- Developed a DGRT prototype with modules for patient plan management, dose reconstruction, dose evaluation, and plan adjustment.
- Utilized electronic portal image device (EPID) for dosimetric calibration and a Monte Carlo Finite-size pencil beam (MCFSPB) model with a Conjugate-gradient (CG) algorithm for 3D dose reconstruction.
- Incorporated 3D Gamma analysis and dose-volume histogram (DVH) analysis for dose evaluation and treatment plan re-optimization.
Main Results:
- Experiments using a head phantom validated the DGRT prototype's functionality.
- Discrepancies between reconstructed and planned doses were observed due to positional errors or inaccurate accelerator delivery.
Conclusions:
- An effective prototype for dose-guided radiation therapy (DGRT) has been successfully developed.
- The developed techniques pave the way for the clinical implementation of DGRT in the near future.
