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Published on: January 28, 2019
Clinical and Molecular Characteristics of Human Rotavirus G8P[8] Outbreak Strain, Japan, 2014
Abstract:
During March-July 2014, rotavirus G8P[8] emerged as the predominant cause of rotavirus gastroenteritis among children in Hokkaido Prefecture, Japan. Clinical characteristics were similar for infections caused by G8 and non-G8 strains. Sequence and phylogenetic analyses suggest the strains were generated by multiple reassortment events between DS-1-like P[8] strains and bovine strains from Asia.
Insights
Rotavirus G8P[8] became the main cause of gastroenteritis in Hokkaido children in 2014. Phylogenetic analysis revealed these strains likely originated from reassortment events involving bovine strains.
Area of Science:
- Virology
- Infectious Diseases
- Public Health
Background:
- Rotavirus is a leading cause of severe gastroenteritis in children worldwide.
- Genotyping of rotavirus strains is crucial for epidemiological surveillance and vaccine development.
Purpose of the Study:
- To investigate the emergence and characteristics of rotavirus strains in Hokkaido Prefecture, Japan, between March and July 2014.
- To determine the genetic origins of the predominant rotavirus strains.
Main Methods:
- Clinical data collection from children with rotavirus gastroenteritis.
- Rotavirus strain identification and genotyping (G and P types).
- Sequence and phylogenetic analyses of viral genes.
Main Results:
- Rotavirus G8P[8] emerged as the predominant strain during the study period.
- Clinical symptoms of G8P[8] infections were comparable to those of other rotavirus strains.
- Phylogenetic analysis indicated that G8P[8] strains resulted from reassortment between DS-1-like P[8] and Asian bovine rotavirus strains.
Conclusions:
- The emergence of rotavirus G8P[8] highlights the dynamic nature of rotavirus epidemiology.
- Understanding the genetic origins of emerging strains is essential for predicting future outbreaks and informing public health strategies.
