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MO-D-BRB-11: Out-Of-Field Dose Measurements in Radiotherapy Using Photons and Particles.

R Kaderka1,2,3, M Durante1,2,3, T Berger1,2,3

  • 1GSI Helmholtzzentrum für Schwerionenforschung, Darmstadt.

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|May 19, 2017
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Summary
This summary is machine-generated.

Charged particle radiotherapy significantly reduces out-of-field dose compared to photons, lowering secondary cancer risks. This study highlights the physical advantages of particle therapy for patient safety.

Keywords:
BrainCancerDiamondDosimetryNeutronsPhotonsRadiation therapySpatial resolutionTherapeuticsThermoluminescent dosimeters

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Area of Science:

  • Medical Physics
  • Radiation Oncology
  • Radiotherapy Dosimetry

Background:

  • Investigating out-of-field dose is crucial for evaluating secondary malignancy risks in radiotherapy.
  • Different radiotherapy modalities, including photons and charged particles, have varying dose distributions.
  • The European ALLEGRO project (grant agreement no. 231965) funded research into these dose distributions.

Purpose of the Study:

  • To compare the out-of-field dose delivered by photon and particle radiotherapy.
  • To evaluate the risk of inducing secondary malignancies by comparing dose distributions in water and anthropomorphic phantoms.
  • To assess the effectiveness of different particle delivery techniques (passive vs. scanning) in reducing out-of-field dose.

Main Methods:

  • Systematic comparison using standardized experiments in water and anthropomorphic phantoms.
  • Dose measurements using a PTW diamond detector, TLDs, and bubble detectors.
  • Irradiations conducted at six facilities using photons, protons, and carbon ions (passive and scanning techniques).

Main Results:

  • Significant differences in out-of-field dose profiles observed beyond 3 cm from the target.
  • Photon therapy delivered 10 to 400 times higher out-of-field doses compared to charged particles.
  • Scanning ion techniques reduced out-of-field dose more effectively than passive delivery at distances >10 cm.

Conclusions:

  • Charged particle therapy offers a physical advantage over photons due to more favorable depth dose deposition.
  • Ions spare surrounding normal tissues more efficiently, implying a lower risk of long-term effects like secondary malignancies.
  • Particle therapy presents a reduced risk of secondary malignancies compared to photon treatments.