SU-E-J-161: Biomechanical Framework for Thoracic Tumors Characteristics.
D Michalski1, G Kubicek1, D Heron1
1University of Pittsburgh Medical Center, Pittsburgh, PA.
Medical Physics
|May 19, 2017
Summary
This study used a biomechanical framework and 4DCT scans to analyze thoracic tumor motion, finding minimal deformation. This objective method can assess anatomical changes during treatment and may predict therapeutic success.
Area of Science:
- Medical Physics
- Biomechanics
- Radiotherapy
Background:
- Respiration causes thoracic tumor movement, complicating radiotherapy.
- Characterizing tumor kinematics is crucial for accurate treatment planning.
Purpose of the Study:
- To apply a biomechanical framework using strain analysis to objectively characterize thoracic tumor kinematics.
- To evaluate the feasibility of using this framework for quantitative assessment of tumor motion and deformation.
Main Methods:
- Utilized 4DCT scans (4-dimensional computed tomography) to obtain tumor displacements between inhalation and exhalation phases.
- Calculated the averaged right Cauchy-Green strain tensor for 15 thoracic Gross Tumor Volumes (GTVs) using Log-Euclidean averaging.
- Determined fractional and geodesic anisotropy of the strain tensor to quantify deformation.
Main Results:
- GTV motion amplitude averaged 1.2 cm, with sizes ranging from 5.16 to 149.99 cc.
- Insignificant tumor deformation was observed, with Log-Euclidean distances from the identity matrix averaging 0.19.
- Low fractional (average 0.07) and geodesic (average 0.09) anisotropy further indicated minimal deformation.
Conclusions:
- A biomechanical framework provides objective, quantitative characterization of thoracic tumor kinematics.
- This method enables non-interpretive evaluation of anatomical changes during and after treatment.
- Objective biomechanical characteristics may correlate with treatment outcomes and predict therapeutic success.
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