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Epigenomics, Pharmacoepigenomics, and Personalized Medicine in Cervical Cancer

Shama Prasada Kabekkodu1, Sanjiban Chakrabarty, Supriti Ghosh

  • 1Department of Cell and Molecular Biology, School of Life Sciences, Manipal University, Karnataka, India.

Public Health Genomics
|May 19, 2017
PubMed

Insights

Epigenomics studies genome-wide epigenetic modifications like DNA methylation and histone changes. This review details epigenetics

Area of Science:

  • Epigenomics
  • Molecular Biology
  • Genetics

Background:

  • Epigenetic modifications (DNA methylation, histone modifications, noncoding RNAs) alter gene expression.
  • These modifications play a crucial role in human diseases, including cancer.
  • Previous research has mapped epigenetic codes and pathways in normal and pathological conditions.

Purpose of the Study:

  • To review recent developments in epigenetics.
  • To explore the impact of epigenetics on personalized medicine for cervical cancer management.

Main Methods:

  • Literature review of recent advancements in epigenetics.
  • Analysis of epigenetic modifications in relation to gene expression and disease pathways.
  • Focus on therapeutic targets in epigenetic pathways.

Main Results:

  • Epigenetic modifications are key regulators of transcriptional events.
  • Epigenetic pathways are implicated in carcinogenesis.
  • Drug discovery targeting epigenetic enzymes offers therapeutic potential for cancer.

Conclusions:

  • Epigenetics is vital for understanding and managing cervical cancer.
  • Personalized medicine approaches incorporating epigenetic insights are promising.
  • Targeting epigenetic modulators represents a significant therapeutic opportunity.
Keywords:
Cervical cancerEpigeneticsPersonalized medicineRisk factors

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