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Stuart Kim1, John P Kleimeyer2, Marwa A Ahmed3

  • 1Dev. Bio., Stanford University, Stanford, United States.

International Journal of Sports Medicine
|May 19, 2017
PubMed
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A specific gene variant, rs12913965, is linked to an increased risk of shoulder dislocation in athletes. This discovery could lead to genetic screening for injury predisposition.

Area of Science:

  • Genetics
  • Orthopedics
  • Sports Medicine

Background:

  • Shoulder dislocations are frequent injuries in contact sports.
  • Understanding genetic factors may reveal injury mechanisms and identify at-risk individuals.

Purpose of the Study:

  • To identify DNA polymorphisms associated with shoulder dislocation.
  • To explore potential genetic markers for predicting shoulder dislocation risk.

Main Methods:

  • Genome-wide association study using public data.
  • Analysis of 662 shoulder dislocation cases and 82,602 controls from European ancestry.

Main Results:

  • rs12913965 demonstrated genome-wide significant association with shoulder dislocation (p=9.7×10⁻⁹).

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  • Carrying one copy of the T allele at rs12913965 increased risk by 69%.
  • rs12913965 is near the TICRR gene and associated with ISG20 gene expression changes.

    • Conclusions:

    • rs12913965 represents a potential genetic marker for shoulder dislocation risk.
    • Future studies are needed to validate this finding and its clinical utility.