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Related Concept Videos

Tumor Immunotherapy01:27

Tumor Immunotherapy

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Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
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Cancer Therapies02:49

Cancer Therapies

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Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
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Targeted Cancer Therapies02:57

Targeted Cancer Therapies

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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
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Cancer Vaccines01:30

Cancer Vaccines

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Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
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Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

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Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
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The Tumor Microenvironment02:17

The Tumor Microenvironment

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Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
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Related Experiment Video

Updated: Mar 2, 2026

Pretargeted Radioimmunotherapy Based on the Inverse Electron Demand Diels-Alder Reaction
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[Immunotherapy and radiotherapy].

S Bockel1, D Antoni2, É Deutsch3

  • 1Département universitaire de radiothérapie, centre Paul-Strauss, 3, rue de la Porte-de-l'Hôpital, 67065 Strasbourg cedex, France.

Cancer Radiotherapie : Journal De La Societe Francaise De Radiotherapie Oncologique
|May 20, 2017
PubMed
Summary
This summary is machine-generated.

Radiotherapy can trigger systemic anti-tumor immunity, causing regression in distant tumors. Combining radiation with immunotherapy enhances this effect, improving cancer treatment potential.

Keywords:
AbscopalImmunotherapyImmunothérapieRadiotherapyRadiothérapie

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Area of Science:

  • Oncology
  • Immunology
  • Radiation Oncology

Background:

  • Radiotherapy induces DNA damage, leading to immunogenic cell death and release of tumor antigens.
  • This can stimulate a systemic anti-tumor immune response, potentially causing regression of non-irradiated tumors (abscopal effect).
  • However, radiotherapy alone rarely achieves significant abscopal effects due to tumor microenvironment immunosuppression.

Purpose of the Study:

  • To explore the mechanisms by which ionizing radiation induces anti-tumor immunity.
  • To review the synergistic effects of combining radiotherapy with immunotherapy.
  • To highlight recent research on combined treatment strategies for enhanced cancer therapy.

Main Methods:

  • Review of scientific literature and preclinical studies.
  • Analysis of mechanisms of immune evasion by cancer.
  • Summary of research on combined radiation and immunotherapy.

Main Results:

  • Radiotherapy can induce immunogenic cell death, releasing neoantigens and inflammatory mediators.
  • The combination of radiotherapy and immunotherapy demonstrates synergistic effects in enhancing anti-tumor immunity.
  • Preclinical and clinical studies show promising results for combined treatment approaches.

Conclusions:

  • Radiotherapy has the potential to induce systemic anti-tumor immunity.
  • Combining radiotherapy with immunotherapy significantly enhances anti-tumor responses and the abscopal effect.
  • This combination therapy holds great promise for improving future cancer treatments.