One-year symptom trajectories in patients with stable schizophrenia maintained on antipsychotics versus placebo:

Hiroyoshi Takeuchi1, Navot Kantor2, Marcos Sanches2

  • 1Hiroyoshi Takeuchi, MD, PhD, Schizophrenia Division, Complex Care & Recovery Program, Centre for Addiction and Mental Health, Toronto, Department of Psychiatry, University of Toronto, Toronto, Canada, and Department of Neuropsychiatry, Keio University School of Medicine, Tokyo, Japan; Navot Kantor, BSc, Faculty of Medicine, University of Ottawa, Ottawa, Canada; Marcos Sanches, MSc, Biostatistical Consulting Service, Clinical Research Department, Centre for Addiction and Mental Health, Toronto, Canada; Gagan Fervaha, BSc, Schizophrenia Division, Complex Care & Recovery Program, Centre for Addiction and Mental Health, Toronto, and Institute of Medical Science, University of Toronto, Toronto, Canada; Ofer Agid, MD, Schizophrenia Division, Complex Care & Recovery Program, Centre for Addiction and Mental Health, Toronto, Department of Psychiatry and Institute of Medical Science, University of Toronto, Toronto, Canada; Gary Remington, MD, PhD, FRCPC, Schizophrenia Division, Complex Care & Recovery Program, Centre for Addiction and Mental Health, Toronto, Department of Psychiatry and Institute of Medical Science, University of Toronto, Toronto, and Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Canada hirotak@dk9.so-net.ne.jp.

Related Concept Videos

Psychosis: Goals of Pharmacotherapy01:26

Psychosis: Goals of Pharmacotherapy

Antipsychotic drugs are a crucial treatment method for acute and chronic psychoses, bipolar illness, and behavioral disorders. The selection of these drugs depends on several factors, including the state of the disease, clinical judgment, possible drug interactions, and the patient's sensitivity to adverse effects. In immediate scenarios, such as delirium and dementia, short-term treatment with low doses of high-potency typical or atypical agents can effectively manage symptom exacerbation.
642
Psychosis and Antipsychotic Drugs: Overview01:28

Psychosis and Antipsychotic Drugs: Overview

The term "psychosis" refers to a spectrum of mental disorders characterized by abnormal thoughts, perceptions, and behaviors. It can manifest as mood disorders, dementia, delirium with psychotic features, substance-induced psychosis with psychotic features, brief psychotic disorder, delusional disorder, schizoaffective disorder, and schizophrenia. Among all these disorders, schizophrenia is the most common psychotic disorder, affecting 1% of the worldwide population. Psychotic...
1.1K
Drug Therapy01:28

Drug Therapy

The advent of drug therapy has profoundly shaped modern mental health care, providing targeted treatments for a range of psychological disorders. Psychotherapeutic drugs, classified into antianxiety, antidepressant, and antipsychotic medications, address symptoms across anxiety disorders, mood disorders, and schizophrenia. While these medications have transformed patient outcomes, they require careful management due to their potential side effects and limitations.
Antianxiety Medications
333
Psychological and Sociocultural Causes of Schizophrenia01:29

Psychological and Sociocultural Causes of Schizophrenia

Schizophrenia, a complex psychiatric disorder, has been historically misunderstood. Early psychological theories attributed its origins to childhood trauma and unresponsive parenting. However, contemporary research largely rejects these notions, favoring the vulnerability-stress hypothesis. This model proposes that individuals with a genetic predisposition to schizophrenia may develop the disorder following exposure to significant environmental stressors. Notably, studies on high-risk...
719
Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders01:27

Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders

Schizophrenia is a neurodevelopmental disorder whose origins are rooted in complex genetic components. Despite our burgeoning understanding, the pathophysiology of this disorder remains incompletely deciphered.
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within...
2.3K
Antipsychotic Drugs: Typical and Atypical Agents01:21

Antipsychotic Drugs: Typical and Atypical Agents

Antipsychotic drugs are classified into first-generation (typical) drugs including phenothiazines; and second-generation (atypical) drugs. Chlorpromazine hydrochloride (Thorazine), a phenothiazine derivative, broadly impacts the central, autonomic, and endocrine systems. This drug, along with typical agents like haloperidol (Haldol), primarily works by antagonizing D2 receptors, thus reducing dopaminergic neurotransmission. However, typical antipsychotics can cause side effects such as sedation...
1.1K