Related Experiment Video
Updated: Mar 2, 2026

Development of a Virtual Reality Assessment of Everyday Living Skills
Published on: April 23, 2014
One-year symptom trajectories in patients with stable schizophrenia maintained on antipsychotics versus placebo:
Hiroyoshi Takeuchi1, Navot Kantor2, Marcos Sanches2
1Hiroyoshi Takeuchi, MD, PhD, Schizophrenia Division, Complex Care & Recovery Program, Centre for Addiction and Mental Health, Toronto, Department of Psychiatry, University of Toronto, Toronto, Canada, and Department of Neuropsychiatry, Keio University School of Medicine, Tokyo, Japan; Navot Kantor, BSc, Faculty of Medicine, University of Ottawa, Ottawa, Canada; Marcos Sanches, MSc, Biostatistical Consulting Service, Clinical Research Department, Centre for Addiction and Mental Health, Toronto, Canada; Gagan Fervaha, BSc, Schizophrenia Division, Complex Care & Recovery Program, Centre for Addiction and Mental Health, Toronto, and Institute of Medical Science, University of Toronto, Toronto, Canada; Ofer Agid, MD, Schizophrenia Division, Complex Care & Recovery Program, Centre for Addiction and Mental Health, Toronto, Department of Psychiatry and Institute of Medical Science, University of Toronto, Toronto, Canada; Gary Remington, MD, PhD, FRCPC, Schizophrenia Division, Complex Care & Recovery Program, Centre for Addiction and Mental Health, Toronto, Department of Psychiatry and Institute of Medical Science, University of Toronto, Toronto, and Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Canada hirotak@dk9.so-net.ne.jp.
Abstract:
BackgroundAs definitions of relapse differ substantially between studies, in investigations involving data aggregation, total scores on clinical rating scales provide a more generalisable outcome.AimsTo compare total symptom trajectories for antipsychotic versus placebo treatment over a 1-year period of maintenance treatment in schizophrenia.MethodRandomised controlled trials with antipsychotic and placebo treatment arms in patients with stable schizophrenia that reported Positive and Negative Syndrome Scale and Brief Psychiatric Rating Scale total scores at more than one time point were included. Meta-regression analyses were employed using a mixed model.ResultsA total of 11 studies involving 2826 patients were included. Meta-regression analyses revealed significant interactions between group and time (PS<0.0001); both standardised total scores and per cent score changes remained almost unchanged in patients continuing antipsychotic treatment, whereas symptoms continuously worsened over time in those switching to placebo treatment.ConclusionsWhen considering long-term antipsychotic treatment of schizophrenia, clinicians must balance symptomatic and functional outcomes.
More Related Videos
10:46A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data
Published on: December 9, 2015
05:52Handwriting Analysis Indicates Spontaneous Dyskinesias in Neuroleptic Naïve Adolescents at High Risk for Psychosis
Published on: November 21, 2013
Related Concept Videos
Psychosis: Goals of Pharmacotherapy
Psychosis and Antipsychotic Drugs: Overview
Drug Therapy
Antianxiety Medications
Psychological and Sociocultural Causes of Schizophrenia
Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within...
Antipsychotic Drugs: Typical and Atypical Agents