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Inflammatory Bowel Disease I: Ulcerative Colitis01:27

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Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
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Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
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Surgical interventions for inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's disease, are essential in managing symptoms and addressing complications. The selection of surgical procedures is contingent upon the specific conditions and complications that stem from these illnesses.
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Protein-losing pseudomembranous colitis with cap polyposis-like features.

Wolfgang Kreisel1, Guenther Ruf1, Richard Salm1

  • 1Wolfgang Kreisel, Bertram Bengsch, Anna-Maria Globig, Department of Medicine II, Gastroenterology, Hepatology, Endocrinology and Infectious Diseases, Medical Center, University of Freiburg, Faculty of Medicine, University of Freiburg, 79106 Freiburg, Germany.

World Journal of Gastroenterology
|May 20, 2017
PubMed
Summary

Protein-losing enteropathy (PLE) is a condition where serum proteins are lost into the GI tract. This case highlights pseudomembranous colitis with cap polyposis-like features as a rare cause of severe PLE.

Keywords:
Cap polyposisGoblet cellsProtein-losing enteropathyPseudomembranesUlcerative colitis

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Area of Science:

  • Gastroenterology
  • Pathology

Background:

  • Protein-losing enteropathy (PLE) involves excessive loss of serum proteins into the gastrointestinal tract, often leading to hypoproteinemia and edema.
  • The small intestine is typically the primary site of protein loss in PLE.

Observation:

  • A 55-year-old female presented with severe PLE, characterized by a year of recurrent diarrhea, abdominal pain, and peripheral edema.
  • Endoscopy and MRI revealed diffuse inflammatory thickening of the sigmoid colon and rectum.

Findings:

  • Surgical resection of the affected colon led to significant symptom resolution.
  • Histologic evaluation confirmed pseudomembranous colitis with cap polyposis-like features as the underlying cause.

Implications:

  • This case describes a previously unreported cause of protein-losing enteropathy.
  • Highlights the colon, specifically pseudomembranous colitis with cap polyposis-like features, as a potential site for PLE.