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Combinatorial therapeutic approaches with RNAi and anticancer drugs using nanodrug delivery systems

Anish Babu1,2, Anupama Munshi2,3, Rajagopal Ramesh1,2,4

  • 1a Department of Pathology , University of Oklahoma Health Sciences Center , Oklahoma City , OK , USA.

Drug Development and Industrial Pharmacy
|May 20, 2017
PubMed

Insights

Small interfering RNA (siRNA) combined with chemotherapy offers a potent cancer treatment strategy. Nanocarriers are crucial for co-delivering siRNA and drugs to overcome multidrug resistance and enhance treatment efficacy.

Area of Science:

  • Oncology
  • Nanotechnology
  • Molecular Biology

Background:

  • RNA interference (RNAi) using small interfering RNA (siRNA) is a promising cancer therapy.
  • siRNA can silence genes contributing to drug resistance and chemotherapeutic inactivity.
  • Overcoming multidrug resistance (MDR) is critical for effective cancer treatment.

Purpose of the Study:

  • To review recent advancements in co-delivery systems for siRNA and anticancer drugs.
  • To discuss nanocarrier strategies for combining siRNA and chemotherapeutics.
  • To highlight siRNA targets that enhance therapeutic efficiency and overcome MDR.

Main Methods:

  • Review of current literature on nanoplatforms for siRNA/anticancer drug co-delivery.
  • Categorization of nanocarriers into liposomal/lipid, polymeric, and inorganic systems.
  • Analysis of strategies for enhancing therapeutic effects through combined delivery.

Main Results:

  • Co-delivery systems using nanocarriers are essential for combining siRNA and anticancer drugs.
  • Liposomal, polymeric, and inorganic nanoplatforms are key categories for these systems.
  • Combined therapies demonstrate additive or synergistic effects, improving therapeutic outcomes.

Conclusions:

  • Nanocarrier-mediated co-delivery of siRNA and anticancer drugs is a viable strategy to combat MDR.
  • Optimizing siRNA targets and nanocarrier design can significantly improve cancer treatment efficacy.
  • This approach holds potential for enhanced patient outcomes in oncology.
Keywords:
Cancer therapychemotherapeuticco-deliveryliposomenanoparticlesiRNA

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