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Related Concept Videos

Blood Transfusion and Agglutination02:45

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Related Experiment Video

Updated: Mar 2, 2026

Preparation and Pathogen Inactivation of Double Dose Buffy Coat Platelet Products using the INTERCEPT Blood System
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Pathogen reduction technologies: The pros and cons for platelet transfusion.

Audrey Magron1, Jonathan Laugier1, Patrick Provost1

  • 1a Centre de Recherche du Centre Hospitalier Universitaire de Québec , Faculté de Médecine de l'Université Laval, Département de Microbiologie et Immunologie , Québec , QC , Canada.

Platelets
|May 20, 2017
PubMed
Summary

Pathogen reduction technologies (PRTs) inactivate microbes in platelet concentrates, but their impact on platelet quality and transfusion safety requires further investigation. This review examines PRT advantages and disadvantages in transfusion medicine.

Keywords:
pathogen reduction systemsplateletstransfusion

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Area of Science:

  • Transfusion Medicine
  • Hematology
  • Microbiology

Background:

  • Platelet concentrates (PCs) are stored at room temperature, increasing microbial contamination risk.
  • Pathogen reduction technologies (PRTs) were developed to mitigate microbial risks in blood products.
  • PRTs inactivate nucleic acids, making them suitable for platelet treatment.

Purpose of the Study:

  • To review the literature on pathogen reduction technologies (PRTs) for platelet concentrates.
  • To present the advantages and disadvantages of PRTs in platelet transfusion.
  • To evaluate the impact of PRTs on platelet quality and transfusion safety.

Main Methods:

  • Literature review of studies on PRTs and platelet concentrates.
  • Analysis of data on PRT effectiveness in pathogen inactivation.
  • Evaluation of studies assessing PRT impact on platelet function and safety.

Main Results:

  • PRTs effectively inactivate a wide range of bacteria, viruses, and parasites in platelet concentrates.
  • Concerns exist regarding the safety of PRT-treated platelets due to potential effects on platelet quality and function.
  • The absence of a nucleus in platelets allows for PRT application.

Conclusions:

  • PRTs offer a method to reduce microbial contamination in platelet transfusion.
  • Further research is needed to fully understand the long-term safety and efficacy of PRT-treated platelets.
  • Balancing pathogen reduction with platelet viability is crucial for transfusion medicine.