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Updated: Mar 2, 2026

Preparation and Characterization of Lipophilic Doxorubicin Pro-drug Micelles
Published on: August 2, 2016
A multifunctional nanocomplex for enhanced cell uptake, endosomal escape and improved cancer therapeutic effect
Patrick V Almeida1, Mohammad-Ali Shahbazi1,2, Alexandra Correia1
1Division of Pharmaceutical Chemistry & Technology, Drug Research Program, Faculty of Pharmacy, University of Helsinki, Viikinkaari 5 E (P.O. Box 56), FI-00014 Finland.
Aim:
To evaluate the chemotherapeutic potential of a novel multifunctional nanocomposite encapsulating both porous silicon (PSi) and gold (Au) nanoparticles in a polymeric nanocomplex.
Materials & Methods:
The nanocomposite was physicochemically characterized and evaluated in vitro for biocompatibility, cellular internalization, endosomolytic properties, cytoplasmatic drug delivery and chemotherapeutic efficacy.
Results:
The nanocomposites were successfully produced and exhibited adequate physicochemical properties and superior in vitro cyto- and hemocompatibilities. The encapsulation of PSi nanoparticles in the nanocomplexes significantly enhanced their cellular internalization and enabled their endosomal escape, resulting in the efficient cytoplasmic delivery of these nanosystems. Sorafenib-loaded nanocomposites showed a potent in vitro antiproliferative effect on MDA-MB-231 breast cancer cells.
Conclusion:
The multifunctional nanocomposite herein presented exhibits great potential as a chemotherapeutic nanoplatform.
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