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Updated: Mar 2, 2026
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Assessment of Morphine-induced Hyperalgesia and Analgesic Tolerance in Mice Using Thermal and Mechanical Nociceptive Modalities
Published on: July 29, 2014
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Opioid-Induced Hyperalgesia: Clinical Implications for Advanced Practice Nurses in Oncology
Ann Guastella1, Jessica Latchman1, Cindy S Tofthagen2
1H. Lee Moffitt Cancer and Research Institute.
Clinical Journal of Oncology Nursing
|May 20, 2017
Summary
Opioid-induced hyperalgesia (OIH) is a complex pain condition. Early identification and ongoing assessment by clinicians are crucial for managing patients experiencing increased pain sensitivity while on opioid therapy.
Area of Science:
- Pain Management
- Pharmacology
- Clinical Medicine
Background:
- Opioid-induced hyperalgesia (OIH) presents a significant challenge in managing patients with pain.
- Current understanding of OIH mechanisms and effective treatments remains limited.
- Diagnosis of OIH often relies on exclusion in clinical practice.
Purpose of the Study:
- To highlight the importance of OIH in patient care.
- To emphasize the need for comprehensive assessment strategies for OIH.
- To underscore the benefits of early OIH identification for patient outcomes.
Main Methods:
- Clinical assessment and patient monitoring.
- Review of existing literature on OIH.
- Diagnostic exclusion criteria in pain management.
Main Results:
- OIH is a critical factor influencing pain management.
- Comprehensive patient assessment is necessary for OIH.
- Early detection of OIH improves patient outcomes.
Conclusions:
- Ongoing clinical assessment is vital for patients on opioid therapy.
- Timely identification of OIH can enhance patient care and treatment efficacy.
- Further research into OIH mechanisms and treatments is warranted.
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