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Juxtaglomerular Cell Phenotypic Plasticity.

Alexandre Góes Martini1, A H Jan Danser2

  • 1Division of Pharmacology and Vascular Medicine, Department of Internal Medicine, Erasmus MC, Room EE1418b, Wytemaweg 80, 3015 CN, Rotterdam, The Netherlands.

High Blood Pressure & Cardiovascular Prevention : the Official Journal of the Italian Society of Hypertension
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PubMed
Summary
This summary is machine-generated.

Renin-producing cells in the kidney can change their phenotype, a process called recruitment, under chronic stimulation. This review explores how renin cell plasticity impacts blood pressure and other biological processes.

Keywords:
EpigeneticsJuxtaglomerular apparatusPlatelet-derived growth factor betaReninSignalingmiRNA

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Area of Science:

  • Nephrology
  • Endocrinology
  • Cell Biology

Background:

  • Renin initiates the renin-angiotensin system, crucial for blood pressure regulation.
  • Juxtaglomerular cells in the kidney are the primary source of renin.
  • Normally, renin production maintains physiological homeostasis.

Purpose of the Study:

  • To critically discuss the phenotypic plasticity of renin-producing cells.
  • To explore the phenomenon of renin cell recruitment under chronic stimulation.
  • To connect renin cell plasticity to blood pressure regulation, development, growth, and tissue regeneration.

Main Methods:

  • Literature review and critical discussion of existing research.
  • Analysis of cellular differentiation and phenotypic plasticity mechanisms.
  • Integration of renin cell biology with broader physiological and developmental contexts.

Main Results:

  • Chronic stimulation, such as low-salt diet or antihypertensive therapy, can induce renin cell recruitment.
  • Previously non-renin-producing cells can revert to a renin-producing phenotype.
  • Renin cell plasticity extends beyond blood pressure control to developmental and regenerative processes.

Conclusions:

  • Renin cell recruitment represents a significant form of cellular plasticity.
  • Understanding renin cell plasticity is vital for comprehending blood pressure homeostasis.
  • The review highlights novel roles for renin cells in development, repair, and regeneration.