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Related Concept Videos

Inflammatory Bowel Disease II: Crohn's Disease01:30

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Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
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Crohn's disease is an inflammatory bowel disorder marked by chronic inflammation of the GI tract. Various treatment strategies for Crohn's disease are employed, such as immunomodulatory agents, glucocorticoids, and biologics or anti-TNF therapy. Azathioprine (Imuran), a commonly used immunomodulatory drug for Crohn's disease, is converted in the body to mercaptopurine, which inhibits purine biosynthesis and cell proliferation. Both are utilized in severe cases of Inflammatory Bowel...
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Metastasis02:30

Metastasis

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Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
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Drugs for Treatment of Crohn's Disease in IBD Using Biologic Agents: Anti-TNF01:24

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Tumor Necrosis Factor (TNF), a proinflammatory cytokine, contributes significantly to the inflammation seen in Crohn's disease. It exists as soluble TNF and membrane-bound TNF, with actions mediated through TNF receptors (TNFR). TNFR activation leads to the release of proinflammatory cytokines, T-cell activation, collagen production, and leukocyte migration, all contributing to inflammation in Crohn's disease. Anti-TNF monoclonal antibodies, namely infliximab (Remicade), adalimumab...
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Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

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Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
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Drugs for Treatment of Crohn's Disease in IBD Using Glucocorticoids01:21

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Glucocorticoids, a class of anti-inflammatory drugs, are pivotal in treating moderate to severe Crohn's disease by inducing remission. They exhibit their anti-inflammatory action by inhibiting the production of inflammatory cytokines such as tumor necrosis factor (TNF)-α, interleukin (IL)-1, and chemokines like IL-8. In addition, they reduce the expression of inflammatory cell adhesion molecules and inhibit gene transcription of nitric oxide synthase, phospholipase A2, cyclooxygenase-2...
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Visualization of Estrogen Receptors in Colons of Mice with TNBS-Induced Crohn's Disease using Immunofluorescence
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Metastatic Crohn's Disease.

Deepak N Amarapurkar1, Amey Sonavane2, Anjali D Amarapurkar3

  • 1Consultant Gastroenterologist.

The Journal of the Association of Physicians of India
|May 21, 2017
PubMed
Summary
This summary is machine-generated.

Metastatic Crohn's disease is a rare skin condition. This case highlights its diagnosis in a patient initially thought to have ulcerative colitis, showing the importance of biopsy for metastatic Crohn's disease.

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Area of Science:

  • Gastroenterology
  • Dermatology
  • Pathology

Background:

  • Crohn's disease (CD) is a chronic inflammatory bowel disease.
  • Extraintestinal manifestations (EIMs) of CD can affect various organs.
  • Cutaneous involvement is a rare but recognized EIM of CD.

Observation:

  • A patient initially diagnosed with ulcerative colitis presented with intra-abdominal abscesses.
  • The patient developed ulcerated cutaneous lesions.
  • Skin biopsy revealed noncaseating granulomas, characteristic of metastatic Crohn's disease.

Findings:

  • Metastatic cutaneous Crohn's disease can mimic other conditions, including ulcerative colitis.
  • The diagnostic hallmark is the presence of noncaseating granulomas in the skin, anatomically separate from the gastrointestinal tract or fistulas.
  • This case underscores the importance of thorough histopathological examination for accurate diagnosis.

Implications:

  • Accurate diagnosis of metastatic Crohn's disease is crucial for appropriate management.
  • Early recognition and treatment can lead to favorable patient outcomes.
  • This case contributes to understanding the diverse clinical presentations of Crohn's disease.