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HPV entry into cells.

Pinar Aksoy1, Elinor Y Gottschalk1, Patricio I Meneses1

  • 1Department of Biological Sciences, Fordham University, Bronx, NY, USA.

Mutation Research. Reviews in Mutation Research
|May 23, 2017
PubMed
Summary
This summary is machine-generated.

Human papillomavirus (HPV) causes various cancers and warts. New research aims to block HPV cell entry, potentially leading to broader vaccines and antivirals against all HPV types.

Keywords:
HPV binding entry intracellular trafficking

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Area of Science:

  • Virology
  • Oncology
  • Cell Biology

Background:

  • Human papillomavirus (HPV) is a common sexually transmitted infection linked to cervical, anal, head, and throat cancers, as well as genital warts.
  • Current HPV vaccines are effective but do not cover all cancer-causing strains, leaving an annual gap of approximately 150,000 preventable cancer cases.
  • Understanding HPV's cellular mechanisms is crucial for developing broader preventative strategies.

Purpose of the Study:

  • To review the current knowledge on how HPV binds to cells.
  • To summarize the processes of HPV entry into host cells.
  • To describe the intracellular trafficking of HPV after entry.

Main Methods:

  • This review synthesizes findings from existing scientific literature.
  • It focuses on the molecular and cellular events of HPV infection.
  • Key processes examined include viral attachment, endocytosis, and nuclear import.

Main Results:

  • HPV binding involves specific cellular receptors.
  • Entry mechanisms include endocytosis pathways.
  • Intracellular trafficking facilitates the delivery of viral genetic material to the nucleus.

Conclusions:

  • Identifying common HPV infection pathways is key to developing new vaccines and antivirals.
  • Targeting viral entry and intracellular transport could prevent infections by a wider range of HPV types.
  • Further research into HPV cell biology may lead to universal HPV prevention strategies.