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Human papillomaviruses in epigenetic regulations.
Julia Durzynska1, Krzysztof Lesniewicz2, Elzbieta Poreba1
1Department of Molecular Virology, Institute of Experimental Biology, A. Mickiewicz University, Umultowska 89, 61-614 Poznań, Poland.
Mutation Research. Reviews in Mutation Research
|May 23, 2017
Summary
Human Papillomaviruses (HPVs) drive cancer by altering cell epigenetics. Viral oncoproteins E6 and E7 manipulate host DNA methylation and microRNAs, promoting persistent infection and malignant transformation.
Area of Science:
- Virology
- Cancer Biology
- Epigenetics
Background:
- Human Papillomaviruses (HPVs) are linked to various human cancers.
- Over 200 HPV types exist, classified by cancer risk.
- High-risk HPVs utilize E6 and E7 oncoproteins in carcinogenesis.
Purpose of the Study:
- To review studies on epigenetic regulation in HPV-infected cells.
- To highlight epigenetic changes relevant to HPV-driven cancer progression.
Main Methods:
- Review of scientific literature on HPV and epigenetics.
- Focus on studies demonstrating biological relevance to cancer.
Main Results:
- HPV E6 and E7 oncoproteins induce epigenetic alterations.
- These changes affect DNA methylation, histone modification, and microRNA expression.
- Epigenetic deregulation of oncogenes and tumor suppressors contributes to cancer development.
Conclusions:
- Epigenetic modifications are crucial in HPV-mediated cancer progression.
- Understanding these mechanisms can inform cancer prevention and treatment strategies.
Keywords:
CancerDNA methylationEpigenetic regulationHistone modificationHuman papillomavirusMicro-RNAsMore Related Videos
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