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How to: Establish and run a stool bank.

E M Terveer¹, Y H van Beurden², A Goorhuis³

¹Dept. of Medical Microbiology, Leiden University Medical Center, Leiden, The Netherlands.

Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases

|May 23, 2017

Summary

The Netherlands Donor Feces Bank (NDFB) was established to standardize fecal microbiota transplantation (FMT) for recurrent Clostridium difficile infections (CDI). This review details their procedures for donor screening, sample preparation, and patient treatment.

Keywords:

Clostridium difficile Faecal microbiota transfer Faecal microbiota transplantation Faeces bank Stool bank

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Area of Science:

Microbiology
Gastroenterology
Infectious Diseases

Background:

Faecal microbiota transplantation (FMT) has shown clinical success for recurrent Clostridium difficile infections (CDI) since 2013.
Inconsistent protocols for donor screening, sample preparation, and administration exist globally.
Lack of European consensus on legislative aspects and standardized recommendations for FMT products.

Purpose of the Study:

Establish the Netherlands Donor Feces Bank (NDFB) in 2015 to provide a standardized FMT product.
Develop Standard Operating Procedures (SOPs) for donor recruitment, selection, screening, and sample processing.
Ensure consistent quality and safety for FMT treatments in the Netherlands.

Main Methods:

Detailed donor recruitment and rigorous screening protocols implemented.
Standardized procedures for the preparation, freezing, storage, and distribution of fecal suspensions.
Established protocols for the administration of fecal microbiota suspensions to patients.

Main Results:

Summarized experience in donor recruitment and screening processes.
Detailed methodology for fecal suspension preparation and transfer.
Overview of patient experiences and follow-up after FMT using NDFB-sourced material.

Conclusions:

The NDFB provides a standardized approach to FMT for recurrent CDI.
Established SOPs ensure consistent product quality and safety.
Experience highlights the importance of standardized procedures in FMT implementation.