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Long non-coding RNA expression profiles in gallbladder carcinoma identified using microarray analysis.

Jiwen Wang1,2, Han Liu1, Xiaokun Shen3

  • 1Department of General Surgery, Zhongshan Hospital, General Surgery Institute, Fudan University, Shanghai 200032, P.R. China.

Oncology Letters
|May 23, 2017
PubMed
Summary

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This summary is machine-generated.

This study identifies novel long non-coding RNAs (lncRNAs) altered in gallbladder carcinoma (GBC), suggesting their critical roles in cancer development. Researchers found numerous lncRNAs are dysregulated, with more downregulated than upregulated in GBC tissues.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genomics

Background:

  • Gallbladder carcinoma (GBC) is a prevalent biliary tract cancer with poor prognosis.
  • Long non-coding RNAs (lncRNAs) are implicated in various cancers, but their role in GBC is not well understood.

Purpose of the Study:

  • To investigate lncRNA expression profiles in GBC and identify novel lncRNAs involved in its development.
  • To elucidate the potential functions and signaling pathways associated with differentially expressed lncRNAs in GBC.

Main Methods:

  • Microarray analysis of lncRNA and mRNA expression in human GBC and adjacent tissues.
  • Validation of microarray data using reverse transcription-quantitative polymerase chain reaction (RT-qPCR).
  • Bioinformatic analyses including Gene Ontology, KEGG pathway, and network analysis.
Keywords:
computational biologyexpression profilegallbladder neoplasmsgene microarray analysislong non-coding RNA

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Main Results:

  • Microarray analysis detected 1,758 differentially expressed lncRNAs and 1,254 differentially expressed mRNAs.
  • More lncRNAs were downregulated than upregulated in GBC tissues compared to para-carcinoma tissues.
  • RP11-152P17.2-006 and CTA-941F9.9 were identified as the most upregulated and downregulated lncRNAs, respectively. RT-qPCR confirmed microarray findings.

Conclusions:

  • lncRNA expression is significantly altered in GBC.
  • Novel lncRNAs associated with GBC have been identified.
  • lncRNAs play important roles in the development and progression of GBC.