Gd-EOB-DTPA based magnetic resonance imaging for predicting liver response to portal vein embolization
Janio Szklaruk1, Gustavo Luersen1, Jingfei Ma1
1Janio Szklaruk, Jingfei Ma, Wei Wei, Michelle Underwood, Department of Diagnostic Radiology, the University of Texas MD Anderson Cancer Center, Houston, TX 77030, United States.
Aim:
To evaluate the correlation between degree of kinetic growth (kGR) of the liver following portal vein embolization (PVE) liver and the enhancement of the during the hepatobiliary phase of contrast administration and to evaluate if the enhancement can be used to predict response to PVE prior to the procedure.
Methods:
Seventeen patients were consented for the prospective study. All patients had an MR of the abdomen with Gd-EOB-DTPA. Fourteen patients underwent PVE. The correlation between the kGR of the liver and the degree of enhancement was evaluated with linear regression (strong assumptions) and Spearman's correlation test (rank based, no assumptions). The correlation was examined for the whole liver, segments I, VIII, VII, VI, V, IV, right liver and left liver.
Results:
There was no correlation between the degree of enhancement during the hepatobiliary phase and kGR for any segment, lobe of the liver or whole liver (P = 0.19 to 0.91 by Spearman's correlation test).
Conclusion:
The relative enhancement of the liver during the hepatobiliary phase with Gd-EOB-DTPA cannot be used to predict the liver response to PVE.
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