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Cultured mesenteric vascular smooth muscle cells express dopamine DA1-receptors
A J Balmforth1, F Lyall, J I Morton
1Department of Biochemistry, University of Glasgow, U.K.
European Journal of Pharmacology
|October 18, 1988
Abstract:
Incubation of cultured mesenteric vascular smooth muscle cells with dopamine, in the presence of propranolol, caused an increase in cyclic AMP formation in a concentration-dependent manner (Ka apparent 6.8 +/- 0.5 microM). This effect of dopamine was inhibited by the DA1-receptor antagonist SCH 23390 (Ki = 1 nM). These results suggest that cultured mesenteric vascular smooth muscle cells express DA1-receptors linked to adenylate cyclase.