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Biodegradable galactitol based crosslinked polyesters for controlled release and bone tissue engineering.

Janeni Natarajan1, Sahitya Movva2, Giridhar Madras3

  • 1Centre for Nano Science and Engineering, Indian Institute of Science, Bangalore 560012, India.

Materials Science & Engineering. C, Materials for Biological Applications
|May 24, 2017
PubMed
Summary
This summary is machine-generated.

Researchers developed new biodegradable polymers for bone disorders by adjusting crosslinking. These materials show tunable properties, controlled degradation, and support bone cell growth, offering promise for drug delivery and tissue engineering.

Keywords:
BiodegradableBone regenerationCrosslinkersDrug deliveryPolyestersTuned degradationTuned release

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Area of Science:

  • Biomaterials Science
  • Polymer Chemistry
  • Tissue Engineering

Background:

  • Biodegradable polymers are crucial for developing alternatives to current bone disorder treatments.
  • Polyesters offer a versatile platform for creating novel biomaterials.

Purpose of the Study:

  • To synthesize and characterize biodegradable polyesters for bone disorder applications.
  • To investigate the impact of crosslinking on polymer properties and degradation.
  • To evaluate the potential of these polymers in drug delivery and tissue engineering.

Main Methods:

  • Synthesis of two polyester families: galactiol/adipic acid and galactitol/dodecanedioic acid based.
  • Structural confirmation using Fourier-transform infrared spectroscopy (FTIR) and proton nuclear magnetic resonance (¹H NMR).
  • Thermal and mechanical analysis via differential scanning calorimetry (DSC) and dynamic mechanical analysis (DMA), alongside contact angle, swelling, and in vitro degradation studies.

Main Results:

  • Increased crosslinking led to higher glass transition temperature, modulus, and hydrophobicity, while decreasing swelling.
  • Degradation and dye release rates decreased with increased crosslinking, hydrophobicity, and modulus, following first-order and Higuchi kinetics, respectively.
  • Polymers demonstrated no cytotoxicity and supported osteogenic differentiation in 3D scaffolds.

Conclusions:

  • Biodegradable polymer properties, degradation, and release kinetics can be modulated by selecting appropriate crosslinkers.
  • These tunable biodegradable polymers hold significant potential for advanced drug delivery systems and tissue engineering applications, particularly for bone regeneration.