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Updated: Mar 2, 2026
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Author Spotlight: Advancing Early Detection and Treatment of Gastrointestinal Tumors
Published on: February 16, 2024
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Gastric Cancer as Preventable Disease
Massimo Rugge1, Robert M Genta2, Francesco Di Mario3
1Department of Medicine (DIMED), University of Padua, Padua, Italy; Veneto Tumor Registry, Veneto Region, Padua, Italy.
Summary
Gastric cancer prevention involves eradicating Helicobacter pylori and using endoscopy to detect precancerous changes. This combined approach aims to reduce cancer progression and improve survival rates.
Area of Science:
- Oncology
- Gastroenterology
- Pathology
Background:
- Gastric cancer is a leading cause of cancer death with poor survival rates.
- Over 90% of gastric adenocarcinomas arise from chronic gastric mucosal inflammation.
- Helicobacter pylori infection is a primary cause of gastritis, leading to gastric atrophy and impaired acid secretion.
Purpose of the Study:
- To outline the clinicopathologic rationale for gastric cancer prevention.
- To emphasize the importance of primary and secondary prevention strategies.
Main Methods:
- Reviewing evidence on Helicobacter pylori eradication for primary prevention.
- Highlighting the role of endoscopy in secondary prevention.
- Discussing the integration of medical expertise into health policy.
Main Results:
- Combined primary (H. pylori eradication) and secondary (endoscopy) prevention can halt gastric oncogenesis.
- Tailored strategies are necessary based on country-specific factors.
Conclusions:
- A multidisciplinary approach integrating gastroenterology, oncology, and pathology is crucial for effective gastric cancer prevention.
- Public health policies should incorporate these combined prevention strategies.
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