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A Reversible, Non-invasive Method for Airway Resistance Measurements and Bronchoalveolar Lavage Fluid Sampling in Mice
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A Reversible, Non-invasive Method for Airway Resistance Measurements and Bronchoalveolar Lavage Fluid Sampling in Mice

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[Effect of nedocromil sodium on the hyperreactivity of the bronchial system in young asthmatic patients]

C P Bauer1, P Emmrich

  • 1Kinderklinik und Kinderpoliklinik der Technischen Universität München.

Monatsschrift Kinderheilkunde : Organ Der Deutschen Gesellschaft Fur Kinderheilkunde
|December 1, 1988
PubMed

Insights

Nedocromil sodium effectively protected asthmatic children from exercise-induced lung function impairment. This study found significantly less lung function decline with nedocromil sodium compared to placebo, with no observed side effects.

Area of Science:

  • Pediatric Pulmonology
  • Clinical Pharmacology

Background:

  • Asthma is a common chronic respiratory disease in children.
  • Exercise-induced bronchoconstriction (EIB) is a frequent trigger for asthma symptoms in pediatric populations.

Purpose of the Study:

  • To evaluate the efficacy of nedocromil sodium in preventing exercise-induced lung function impairment in asthmatic children.
  • To compare the protective effects of nedocromil sodium against a placebo in a controlled trial.

Main Methods:

  • A placebo-controlled, double-blind, randomized crossover trial design was employed.
  • Participants included children diagnosed with asthma.
  • Exercise provocation tests were used to assess lung function before and after challenge.

Main Results:

  • Nedocromil sodium significantly reduced lung function impairment during exercise compared to placebo (p < 0.05).
  • The maximum decrease in lung function post-exercise was significantly less with nedocromil sodium (p < 0.05).
  • No adverse side effects were reported during the study period.

Conclusions:

  • Nedocromil sodium demonstrates a significant protective effect against exercise-induced bronchoconstriction in asthmatic children.
  • The medication is well-tolerated, showing no adverse events in the studied pediatric population.

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