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[Non-polio enterovirus in France from 1974 to 1985. Data collected from a system of 30 hospital virology
J Celers1, P Celers, A Bertocchi
1Laboratoire National de la Santé, Paris, France.
Abstract:
A total of 12,097 isolates of NPEV was reported in France from 1974 through 1985 by 30 volunteers laboratories (71% of all virology laboratories). The 14 most common types which accounted for 75% of all isolates are echoviruses 4, 6, 7, 9, 11, 14, 30 and 33, coxsackieviruses A9, B1 to B5. Among them, 12 are equally reported as the most common types isolated in the United States from 1970 through 1983. Echoviruses 14 and 33 are specially found in France; Echoviruses 3 and 5 in the United States. We can estimate that those 16 types are the most common EVNP in human pathology. The pattern of each type is different in the United States and in France: it seems not possible to assign an epidemic character specific to each of them. Yet epidemic types accounted for 13 to 27% of isolates in March, April, May. Among clinical manifestations, aseptic meningitis are the most frequently reported: 37% of 3,619 cases. Echoviruses are significantly most often associated with meningitis than coxsackieviruses (p less than 0.001) and coxsackieviruses more often associated with other neurological manifestations, myocarditis and pericarditis. From these results wa can suggest to simplify the typing procedures of NPEV for routine diagnosis.
Insights
This study analyzed 12,097 nonpolio enterovirus (NPEV) isolates in France, identifying common types and their association with aseptic meningitis. Findings suggest simplifying NPEV typing for routine diagnostics.
Area of Science:
- Virology
- Epidemiology
- Clinical Microbiology
Background:
- Nonpolio enteroviruses (NPEV) are significant human pathogens.
- Understanding the epidemiology and clinical associations of NPEV is crucial for public health.
Purpose of the Study:
- To analyze the prevalence and distribution of NPEV types in France from 1974-1985.
- To compare French NPEV data with US data.
- To investigate the clinical manifestations associated with different NPEV types.
Main Methods:
- Retrospective analysis of 12,097 NPEV isolates reported by volunteer laboratories in France.
- Comparison of prevalent NPEV types with data from the United States.
- Correlation of NPEV types with reported clinical manifestations, including aseptic meningitis.
Main Results:
- 16 NPEV types were identified as most common, with 12 overlapping between France and the US.
- Echoviruses 14 and 33 were notably prevalent in France, while Echoviruses 3 and 5 were more common in the US.
- Aseptic meningitis was the most frequent clinical manifestation (37%), with echoviruses more strongly associated than coxsackieviruses.
Conclusions:
- The study identified the most common NPEV types in France and highlighted regional differences compared to the US.
- Echoviruses and coxsackieviruses show distinct clinical associations, with echoviruses linked to meningitis.
- Simplification of NPEV typing procedures for routine diagnosis is recommended based on these findings.