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Time-dependent haemoperfusion after acute paraquat poisoning
Hao-Ru Wang1, Jian Pan1, An-Dong Shang1
1Department of Emergency Medicine, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310003, People's Republic of China.
Scientific Reports
|May 24, 2017
Summary
Early haemoperfusion (HP) therapy is crucial for acute paraquat (PQ) poisoning survival. Initiating HP within 4 hours, followed by a second treatment within 20 hours, significantly improves patient outcomes.
Area of Science:
- Toxicology
- Nephrology
- Pulmonology
Background:
- Acute paraquat (PQ) poisoning is a significant health concern.
- Early haemoperfusion (HP) therapy shows promise, but optimal timing remains unclear.
Purpose of the Study:
- To determine the effective therapeutic window for haemoperfusion (HP) in acute paraquat (PQ) poisoning.
- To identify independent factors influencing survival in PQ poisoning patients.
Main Methods:
- Retrospective study of 621 patients with acute PQ poisoning.
- Analysis included demographic data, therapies, and confounding factors.
- Receiver operating characteristic (ROC) curve analysis and subgroup analysis were performed.
Main Results:
- Initiating HP within 4 hours, with a second treatment within 20 hours, was critical for survival.
- Positive PQ urine test, pulmonary lesions within 8 days, and stage III AKI were independent survival factors.
- Glucocorticoid therapy initiated within 3 hours also showed a positive impact.
Conclusions:
- Timely initiation of haemoperfusion (HP) is paramount for improving survival in acute paraquat (PQ) poisoning.
- The therapeutic window for HP is crucial, emphasizing early intervention.
- Multiple factors, including renal and pulmonary status, influence patient prognosis.
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