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Related Concept Videos

Computed Tomography01:10

Computed Tomography

9.2K
Tomography refers to imaging by sections. Computed tomography (CT) is a non-invasive imaging technique that uses computers to analyze several cross-sectional X-rays to reveal minute details about structures in the body.
The technique was invented in the 1970s and is based on the principle that as X-rays pass through the body, they are absorbed or reflected at different levels. In the technique, a patient lies on a motorized platform while a computerized axial tomography (CAT) scanner rotates...
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Imaging Studies for Cardiovascular System V: CT01:28

Imaging Studies for Cardiovascular System V: CT

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Cardiac computed tomography (CT) scanning is an advanced cardiac imaging technique that utilizes CT technology, with or without intravenous (IV) contrast, to produce accurate cross-sectional virtual slices of specific areas of the heart, coronary circulation, and major blood vessels such as the aorta, pulmonary veins, and arteries. The computer processes these slices to generate three-dimensional images. Multidetector CT (MDCT) is a rapid form of CT scanning that captures multiple slices...
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Ultrasound Based Assessment of Coronary Artery Flow and Coronary Flow Reserve Using the Pressure Overload Model in Mice
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Fractional flow reserve based on computed tomography: an overview.

Francesco Secchi1, Marco Alì2, Elena Faggiano3

  • 1Unit of Radiology, IRCCS Policlinico San Donato, Via Morandi 30, San Donato Milanese, Milan 20097, Italy.

European Heart Journal Supplements : Journal of the European Society of Cardiology
|May 24, 2017
PubMed
Summary

Computed tomographic fractional flow reserve (CT-FFR) offers a non-invasive way to assess coronary artery disease (CAD) functional significance. This technique enhances diagnostic accuracy for intermediate stenoses, improving patient management.

Keywords:
Computed tomographyCoronary artery diseaseFractional flow reserveTransluminal attenuation gradient

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Area of Science:

  • Cardiology
  • Medical Imaging
  • Computational Fluid Dynamics

Background:

  • Computed tomography coronary angiography (CTCA) excels at identifying coronary artery disease (CAD) anatomy.
  • CTCA's limitation is its inability to assess the functional significance of coronary stenoses.
  • Intermediate-grade stenoses require functional assessment for accurate diagnosis and treatment.

Purpose of the Study:

  • To review the methods and evidence for computed tomographic fractional flow reserve (CT-FFR).
  • To compare CT-FFR with invasive fractional flow reserve (FFR) for clinical applications.
  • To evaluate the cost-benefit of CT-FFR in patient management and health outcomes.

Main Methods:

  • Summarizing methods for CT-FFR calculation using CTCA data.
  • Reviewing literature including 16 original articles and one meta-analysis up to June 26, 2016.
  • Comparing CT-FFR with invasive FFR in terms of technical characteristics and clinical utility.

Main Results:

  • CT-FFR provides a non-invasive assessment of functional haemodynamic significance.
  • Evidence suggests CT-FFR can impact CAD diagnosis, prognosis, and treatment decisions.
  • The review synthesizes existing data on CT-FFR's performance and applications.

Conclusions:

  • CT-FFR is a promising non-invasive tool for evaluating coronary artery disease.
  • It addresses the functional assessment limitation of traditional CTCA.
  • CT-FFR has the potential to significantly influence clinical decision-making in CAD management.