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[Primary colonic extranasal NK/T-cell lymphoma: about a case]
Salma Fares1, Mouna Lamchahab1, Myriem Aniba1
1Service d'Hématologie et d'Oncologie Pédiatrique, Hôpital 20 Août 1953, CHU Ibn Rochd, Casablanca, Maroc.
The Pan African Medical Journal
|May 24, 2017
Summary
This case report details a fatal outcome for a 43-year-old with primary colonic NK/T-cell lymphoma. Diagnosis and classification of this rare intestinal lymphoma are challenging.
Area of Science:
- Oncology
- Gastroenterology
- Hematology
Background:
- Primary intestinal Natural Killer/T-cell lymphoma (NKTL) is a rare malignancy, often affecting younger individuals with a poor prognosis.
- Distinguishing intestinal NKTL from inflammatory or infectious conditions is challenging due to non-specific clinical and endoscopic presentations.
Observation:
- A 43-year-old patient presented with localized, isolated primary colonic NKTL without enteropathy.
- The patient showed a poor response to three cycles of AspaMetDex and died during treatment, presenting with an acute abdomen.
Findings:
- Histopathological and immunohistochemical analyses, alongside DNA studies, are crucial for accurate diagnosis.
- Classification can be refined using criteria for European Enteropathy-type T-cell lymphoma (ETL).
Implications:
- This case highlights the diagnostic difficulties and poor prognosis associated with primary intestinal NKTL.
- Standardized diagnostic and classification approaches are essential for managing this rare gastrointestinal lymphoma.
