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Updated: Mar 2, 2026
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Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis
Published on: December 15, 2011
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Thiol/disulphide homeostasis in celiac disease
Mustafa Kaplan1, Ihsan Ates1, Mahmut Yuksel1
1Mustafa Kaplan, Mahmut Yuksel, Yasemin Ozderin Ozin, Ertugrul Kayacetin, Department of Gastroenterology, Turkey Yuksek Ihtisas Training and Research Hospital, 06500 Ankara, Turkey.
Summary
Celiac disease disrupts thiol/disulphide homeostasis, shifting the balance towards disulphide forms. This imbalance correlates with celiac autoantibodies and gluten-free diet adherence.
Area of Science:
- Biochemistry
- Immunology
- Gastroenterology
Background:
- Celiac disease is an autoimmune disorder triggered by gluten ingestion.
- Thiol/disulphide homeostasis plays a crucial role in cellular redox balance.
- Alterations in thiol/disulphide homeostasis are implicated in various inflammatory conditions.
Purpose of the Study:
- To investigate dynamic thiol/disulphide homeostasis in celiac disease patients.
- To examine the association between thiol/disulphide balance, celiac autoantibodies, and gluten-free diet adherence.
Main Methods:
- A colorimetric method was used to assess thiol/disulphide homeostasis.
- The study included 73 celiac disease patients and 73 healthy controls.
Main Results:
- Celiac patients exhibited lower native and total thiol levels, and higher disulphide levels and ratios compared to controls.
- Non-adherence to a gluten-free diet and positive autoantibody status were associated with increased disulphide/native thiol ratios.
- Negative correlations were observed between celiac autoantibodies and thiol levels, and positive correlations with disulphide levels and ratios.
Conclusions:
- Celiac disease is characterized by a shift in thiol/disulphide balance towards the disulphide form.
- This imbalance is linked to disease activity, autoantibody status, and dietary compliance.
Keywords:
Anti-gliadin antibodiesAnti-tissue transglutaminase antibodyGluten-free dietOxidative stressThiol oxidationMore Related Videos
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