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Serum prolidase activity in systemic sclerosis.

Ahmet Celik1, Muhammed Nur Birer2, Metin Kilinc2

  • 1Medical Faculty, Department of Medical Biochemistry, Sutcu Imam University, Kahramanmaras, Turkey. drahmetcelik@gmail.com.

Clinical Rheumatology
|May 24, 2017
PubMed
Summary

Serum prolidase activity (SPA) was investigated in systemic sclerosis patients. SPA was found to be significantly lower in the diffuse subtype compared to limited subtype and healthy controls, indicating potential roles in disease pathogenesis.

Keywords:
CollagenSclerodermaSerum prolidase activity

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Area of Science:

  • Immunology
  • Biochemistry
  • Dermatology

Background:

  • Systemic sclerosis (scleroderma) is an autoimmune disease affecting connective tissues and vasculature.
  • It involves inflammation and excessive collagen synthesis, leading to skin hardening and fibrosis.
  • Prolidase is an enzyme crucial for collagen degradation.

Purpose of the Study:

  • To evaluate serum prolidase activity (SPA) in patients with systemic sclerosis.
  • To compare SPA levels between diffuse cutaneous systemic sclerosis (dSSc) and limited cutaneous systemic sclerosis (lSSc) subtypes.
  • To assess differences in SPA between patients and healthy controls.

Main Methods:

  • A cohort of 35 systemic sclerosis patients (24 dSSc, 11 lSSc) and 41 healthy controls were enrolled.
  • Serum prolidase activity was measured using Myara's method, a modification of Chinard's method.
  • Statistical analysis was performed to compare SPA levels across groups.

Main Results:

  • Overall SPA did not significantly differ between systemic sclerosis patients and controls (p=0.467).
  • SPA was significantly lower in the diffuse subtype compared to both the limited subtype (p=0.021) and controls (p=0.024).
  • No significant difference in SPA was observed between the limited subtype and controls (p=0.145).

Conclusions:

  • Serum prolidase activity is reduced in systemic sclerosis, particularly in the diffuse subtype.
  • This reduction may contribute to the excessive collagen deposition and fibrosis characteristic of scleroderma.
  • Factors like autoantibodies, oxidative stress, and reduced physical activity might influence SPA in scleroderma.