Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Micelles01:30

Micelles

39
Micelle formation is an intricate process that hinges on the properties of amphiphilic or amphipathic molecules and the conditions of the system in which they are found. Amphiphilic molecules, which have both hydrophilic (water-attracting) and hydrophobic (water-repelling) parts, play a critical role in this process.In aqueous environments, these molecules arrange themselves such that their hydrophilic heads are turned towards the water phase, while their hydrophobic tails are oriented away...
39
Entropy and Solvation02:05

Entropy and Solvation

8.6K
The process of surrounding a solute with solvent is called solvation. It involves evenly distributing the solute within the solvent. The rule of thumb for determining a solvent for a given compound is that like dissolves like. A good solvent has molecular characteristics similar to those of the compound to be dissolved. For example, polar solutions dissolve polar solutes, and apolar solvents dissolve apolar solutes. A polar solvent is a solvent that has a high dielectric constant (ϵ...
8.6K
Solubility03:00

Solubility

21.6K
Solution, Solubility, and Solubility Equilibrium
A solution is a homogeneous mixture composed of a solvent, the major component, and a solute, the minor component. The physical state of a solution—solid, liquid, or gas—is typically the same as that of the solvent. Solute concentrations are often described with qualitative terms such as dilute (of relatively low concentration) and concentrated (of relatively high concentration).
In a solution, the solute particles (molecules,...
21.6K
The Colloidal State01:29

The Colloidal State

27
The formation of a colloidal system is exemplified by an aqueous solution containing Cl− ions is introduced to another containing Ag+ ions, resulting in the precipitation of solid AgCl as extremely tiny crystals. Instead of settling out as a filterable precipitate, these crystals remain suspended in the liquid, showcasing a colloidal system.A colloidal system involves colloidal particles within the approximate range of 1 to 1000 nm in at least one dimension, dispersed in a medium called...
27
Intermolecular Forces03:13

Intermolecular Forces

74.3K
Atoms and molecules interact through bonds (or forces): intramolecular and intermolecular. The forces are electrostatic as they arise from interactions (attractive or repulsive) between charged species (permanent, partial, or temporary charges) and exist with varying strengths between ions, polar, nonpolar, and neutral molecules. The different types of intermolecular forces are ion–dipole, dipole–dipole, hydrogen bonds, and dispersion; among these, dipole–dipole, hydrogen...
74.3K
Enthalpy of Solution02:39

Enthalpy of Solution

31.5K
There are two criteria that favor, but do not guarantee, the spontaneous formation of a solution:
31.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Corrigendum to Diffusion MRI measures detect brain microstructure changes due to early treatment with neurotrophic peptide mimetic P021 in the 3xTg-AD mouse model of Alzheimer's disease. Magn Reson Imaging. 2026 Jun;129:110641 Page: 9.

Magnetic resonance imaging·2026
Same author

Diffusion MRI measures detect brain microstructure changes due to early treatment with neurotrophic peptide mimetic P021 in the 3xTg-AD mouse model of Alzheimer's disease.

Magnetic resonance imaging·2026
Same author

Associations between psychosocial work environment factors and first-time and recurrent treatment for depression: a prospective cohort study of 24,226 employees.

Epidemiology and psychiatric sciences·2024
Same author

The effect of synthesis conditions and process parameters on aerogel properties.

Frontiers in chemistry·2023
Same author

Occupational risk of COVID-19 in foreign-born employees in Denmark.

Occupational medicine (Oxford, England)·2023
Same author

Physiological response and yield components under greenhouse drought stress conditions in potato.

Journal of plant physiology·2022

Related Experiment Video

Updated: Mar 2, 2026

Author Spotlight: Advancing Cell Membrane Biophysics - Exploring Interactions and Challenges Through Experimental and Computational Approaches
07:31

Author Spotlight: Advancing Cell Membrane Biophysics - Exploring Interactions and Challenges Through Experimental and Computational Approaches

Published on: September 1, 2023

3.3K

Solute Partitioning in Micelles: Combining Molecular Dynamics Simulations, COSMOmic, and Experiments.

D Yordanova1, E Ritter1, T Gerlach1

  • 1Institute of Thermal Separation Processes, Hamburg University of Technology , Eissendorfer Strasse 38, 21073 Hamburg, Germany.

The Journal of Physical Chemistry. B
|May 24, 2017
PubMed
Summary

Predictive methods for solute partitioning in micelles are crucial. Molecular dynamics (MD) simulations and COSMOmic theory show good agreement for neutral solutes, aiding micellar system applications.

More Related Videos

Assembly and Characterization of Polyelectrolyte Complex Micelles
08:44

Assembly and Characterization of Polyelectrolyte Complex Micelles

Published on: March 2, 2020

11.6K
Reconstitution of Septin Assembly at Membranes to Study Biophysical Properties and Functions
06:32

Reconstitution of Septin Assembly at Membranes to Study Biophysical Properties and Functions

Published on: July 28, 2022

2.7K

Related Experiment Videos

Last Updated: Mar 2, 2026

Author Spotlight: Advancing Cell Membrane Biophysics - Exploring Interactions and Challenges Through Experimental and Computational Approaches
07:31

Author Spotlight: Advancing Cell Membrane Biophysics - Exploring Interactions and Challenges Through Experimental and Computational Approaches

Published on: September 1, 2023

3.3K
Assembly and Characterization of Polyelectrolyte Complex Micelles
08:44

Assembly and Characterization of Polyelectrolyte Complex Micelles

Published on: March 2, 2020

11.6K
Reconstitution of Septin Assembly at Membranes to Study Biophysical Properties and Functions
06:32

Reconstitution of Septin Assembly at Membranes to Study Biophysical Properties and Functions

Published on: July 28, 2022

2.7K

Area of Science:

  • Physical Chemistry
  • Computational Chemistry
  • Supramolecular Chemistry

Background:

  • Solute partitioning between micelles and aqueous phases is vital for various applications.
  • Accurate theoretical prediction of this behavior is needed due to numerous micelle-solute combinations.
  • Experimental data for charged solute partitioning in micelles is scarce.

Purpose of the Study:

  • To evaluate and compare two theoretical methods for predicting solute partitioning in micellar systems.
  • To assess the performance of molecular dynamics (MD) simulations and COSMOmic theory.
  • To investigate the partitioning of both neutral and ionized solutes across different micelle types.

Main Methods:

  • Molecular dynamics (MD) simulations utilizing the umbrella sampling method to compute free energy profiles.
  • Application of COSMOmic, an extension of COSMO-RS theory for anisotropic systems.
  • Experimental determination of micelle/water partition coefficients for validation.
  • Study of diverse micelle classes: nonionic (Triton X-114), zwitterionic (miltefosine), anionic (sodium dodecyl sulfate), and cationic (cetyltrimethylammonium bromide).

Main Results:

  • MD simulations and COSMOmic theory provide comparable free energy profiles for neutral solutes.
  • Both theoretical methods demonstrate good agreement with experimental partition coefficients for neutral solutes.
  • Deviations observed for charged solutes between the two methods and experimental data, depending on the specific system.
  • Experimental data were generated for charged solute partitioning to address data scarcity.

Conclusions:

  • MD simulations and COSMOmic theory are effective for predicting neutral solute partitioning in micelles.
  • The methods show promise but require further refinement for accurate prediction of charged solute partitioning.
  • The study provides valuable insights into micellar partitioning behavior across different solute and micelle types.