Related Experiment Videos
Bradykinin action in the rat duodenum: influence of a duodenum contracting bradykinin partial sequence on the cAMP
1Department of Biology, Friedrich Schiller-University Jena, GDR.
Biomedica Biochimica Acta
|January 1, 1988
Abstract:
A modified bradykinin partial sequence (PP) contracts the isolated rat duodenum, inhibits the adenylate cyclase activity and decreases the cAMP level. These effects are dependent on the presence of free Ca++. The PP acts in contrast to bradykinin itself, which relaxes the rat duodenum and stimulates adenylate cyclase. The results further support the involvement of both cAMP and Ca++ in bradykinin action on rat duodenum smooth muscle.