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A comparative study of serum proteins ability to scavenge active oxygen species: O2-. and OCl-
B P Sharonov1, Govorova NJu, S N Lyzlova
1Department of Biochemistry, Leningrad State University, USSR.
Biochemistry International
|October 1, 1988
Abstract:
The ability of serum proteins (albumin, immunoglobulin G) and protein antioxidants (ceruloplasmin, superoxide dismutase and transferrin) to react with O2-. and OCl-, was studied. The interaction between serum proteins and OCl- was shown to be non-specific. Ceruloplasmin is the most effective OCl- trapping protein, and it reacts with O2-. with a considerable efficiency. Therefore, ceruloplasmin is supposed to be the main scavenger of toxic oxygen species generated by stimulated neutrophils.