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Updated: Mar 2, 2026
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A Simple and Rapid Protocol to Non-enzymatically Dissociate Fresh Human Tissues for the Analysis of Infiltrating Lymphocytes
Published on: December 6, 2014
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Innate Lymphoid Cells in Tumor Immunity.
Jasper J P van Beek1, Anne W J Martens2, Ghaith Bakdash3
1Department of Tumor Immunology, Radboud University Medical Center, Radboud Institute for Molecular Life Sciences, 6525 GA Nijmegen, The Netherlands. Jasper.vanBeek@radboudumc.nl.
Biomedicines
|May 25, 2017
Summary
Innate lymphoid cells (ILCs) are immune cells crucial for tumor immunity. This review explores how different ILC subsets impact cancer progression and treatment resistance, offering insights for cancer monitoring.
Area of Science:
- Immunology
- Cancer Biology
Background:
- Innate lymphoid cells (ILCs) are a diverse group of immune cells lacking antigen specificity.
- Key ILC subsets include natural killer (NK) cells, lymphoid tissue inducer (LTi) cells, ILC1s, ILC2s, and ILC3s.
- While NK cell roles in cancer are known, other ILC subsets' involvement is an emerging area.
Purpose of the Study:
- To review the current literature on the role of various ILC subsets in tumor immunity.
- To discuss the implications of ILC functions in cancer progression and resistance.
- To explore the potential of ILCs in cancer treatment and monitoring strategies.
Main Methods:
- Comprehensive literature review of studies investigating ILCs in cancer.
- Analysis of research on ILC subset functions in tumor microenvironments.
- Synthesis of findings related to ILCs, tumor immunity, and cancer outcomes.
Main Results:
- NK cells have established roles in anti-tumor immunity.
- Emerging evidence highlights diverse functions of ILC1s, ILC2s, and ILC3s in cancer.
- ILC subsets can promote or inhibit tumor growth and influence treatment responses.
Conclusions:
- ILCs represent a critical component of the anti-tumor immune response.
- Understanding ILC subset functions is vital for developing novel cancer immunotherapies.
- Targeting ILCs may offer new avenues for cancer treatment and patient monitoring.
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