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Apathy and Executive Function in Healthy Elderly-Resting State fMRI Study.

Toshikazu Kawagoe1, Keiichi Onoda1, Shuhei Yamaguchi1

  • 1Department of Neurology, Shimane UniversityIzumo, Japan.

Frontiers in Aging Neuroscience
|May 25, 2017
PubMed
Summary

Apathy in healthy older adults is linked to executive dysfunction, potentially due to reduced brain connectivity. This study explores apathy subtypes and cognitive decline in aging populations.

Keywords:
age-related deteriorationcognitive apathyexecutive functionfrontostriatal networkneuroimaging

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Area of Science:

  • Neuroscience
  • Psychology
  • Gerontology

Background:

  • Apathy, a reduction in goal-directed behavior, has subtypes, but the cognitive-deficit subtype linked to executive dysfunction remains understudied in healthy aging.
  • Executive functions (EF) naturally decline with age, yet their specific relationship with apathy in healthy older adults is not well-established.

Purpose of the Study:

  • To investigate the association between apathy and executive function in healthy older adults.
  • To explore potential neural underpinnings, specifically functional connectivity between the striatum and frontal regions, in healthy aging.

Main Methods:

  • Analysis of data from 100 healthy adults within a health examination system database.
  • Assessment of apathy and executive function, alongside neuroimaging to evaluate functional connectivity.

Main Results:

  • A significant association was found between apathy and executive deterioration in healthy older adults.
  • Decreased functional connectivity between the frontal cortex and the ventral striatum partially explains this relationship.

Conclusions:

  • Apathy in healthy aging is substantially linked to executive function decline.
  • Reduced fronto-striatal functional connectivity may be a key neural mechanism contributing to apathy in healthy psychological aging.
  • Findings contribute to understanding cognitive and psychological changes in healthy aging individuals.