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Pregabalin can decrease acute pain and morphine consumption in laparoscopic cholecystectomy patients: A meta-analysis

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Pregabalin effectively reduces postoperative pain and morphine use after laparoscopic cholecystectomy. Higher doses showed greater efficacy, but optimal dosing requires further study.

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Area of Science:

  • Anesthesiology
  • Pharmacology
  • Surgical Pain Management

Background:

  • Pregabalin is utilized as an adjunct therapy for managing acute pain following laparoscopic cholecystectomy.
  • This meta-analysis evaluates the efficacy and safety of pregabalin in this context.

Purpose of the Study:

  • To assess the effectiveness of pregabalin in reducing pain scores post-laparoscopic cholecystectomy.
  • To evaluate the impact of pregabalin on total morphine consumption and related complications.

Main Methods:

  • A systematic literature search was conducted across major databases (PubMed, EMBASE, Web of Science, Cochrane).
  • Included studies compared pregabalin with placebo in patients undergoing laparoscopic cholecystectomy.
  • Primary endpoints included Visual Analog Scale (VAS) pain scores and morphine consumption; secondary outcomes were morphine-related adverse events.

Main Results:

  • Twelve studies with 938 patients were analyzed.
  • Pregabalin significantly reduced VAS pain scores at 6, 12, and 24 hours post-surgery, both at rest and during mobilization.
  • Pregabalin also decreased the incidence of nausea and vomiting, with no significant differences in other assessed complications.

Conclusions:

  • Pregabalin demonstrates efficacy in reducing postoperative pain, morphine consumption, and associated complications after laparoscopic cholecystectomy.
  • Higher doses of pregabalin appear more effective than lower doses.
  • Further research is needed to determine the optimal pregabalin dosage for this patient population due to observed heterogeneity.