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Updated: Mar 1, 2026

The Mouse Round-window Approach for Ototoxic Agent Delivery: A Rapid and Reliable Technique for Inducing Cochlear Cell Degeneration

The Mouse Round-window Approach for Ototoxic Agent Delivery: A Rapid and Reliable Technique for Inducing Cochlear Cell Degeneration

Published on: November 26, 2015

Cochlear function in students exposed to pesticides.

Tatiana Rodrigues Garcia¹, Maria Isabel Kós Pinheiro de Andrade¹, Silvana Maria Frota¹

¹Universidade Federal do Rio de Janeiro - UFRJ - Rio de Janeiro (RJ), Brasil.

|May 25, 2017

Summary

Pesticide exposure in students is linked to reduced cochlear function, impacting hearing at higher frequencies. This study highlights potential hearing damage from environmental chemical exposure.

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Modified Experimental Conditions for Noise-Induced Hearing Loss in Mice and Assessment of Hearing Function and Outer Hair Cell Damage

Modified Experimental Conditions for Noise-Induced Hearing Loss in Mice and Assessment of Hearing Function and Outer Hair Cell Damage

Published on: February 10, 2023

Area of Science:

Environmental Health
Audiology
Toxicology

Background:

Pesticide use is widespread in agricultural and residential areas.
Potential ototoxic effects of pesticides on hearing are not fully understood.
Early detection of cochlear changes is crucial for intervention.

Purpose of the Study:

To investigate the association between pesticide exposure and cochlear function.
To assess hearing alterations in individuals exposed to pesticides.
To determine the risk of pesticide exposure on auditory health.

Main Methods:

Study population: 8-30 year olds in a high pesticide use area.
Data collection: Questionnaires on pesticide exposure and audiometry.
Auditory assessment: Transient Evoked Otoacoustic Emissions (TEOAEs) and Distortion Product Otoacoustic Emissions (DPOAEs).

Main Results:

Lower TEOAE and DPOAE responses at higher frequencies (2-6 kHz) in highly exposed individuals.
Increased failure rates in TEOAE and DPOAE tests among the most exposed groups.
Significant differences in cochlear function indicators between exposure levels.

Conclusions:

Pesticide exposure is associated with significant alterations in cochlear function.
Even with normal audiometric thresholds, pesticide exposure may cause subclinical hearing damage.
Findings underscore the importance of monitoring auditory health in pesticide-exposed populations.