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Updated: Mar 1, 2026
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Analyzing the Functions of Mast Cells In Vivo Using 'Mast Cell Knock-in' Mice
Published on: May 27, 2015
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Mast cells and aging
N A Kutukova1, P G Nazarov1,2,3, G V Kudryavtseva2
1Institute of of Experimental Medicine, Saint-Petersburg, Russian Federation.
Advances in Gerontology = Uspekhi Gerontologii
|May 25, 2017
Summary
Mast cells (MC) regulate physiological processes and are found throughout the body. Alterations in MCs during aging correlate with age-related diseases and neurological disorders.
Area of Science:
- Immunology
- Neuroscience
- Dermatology
Background:
- Mast cells (MCs) are immune cells residing in various tissues, including skin, mucous membranes, and the brain.
- They are strategically positioned near blood vessels, lymphatic vessels, and nerve terminals.
- MCs release numerous biologically active substances upon degranulation, influencing local physiological processes.
Purpose of the Study:
- To investigate the role of mast cells in physiological regulation.
- To explore the association between mast cell changes and aging.
- To understand the link between mast cell activity and age-related neurological and physiological disorders.
Main Methods:
- This study is a review of existing literature on mast cells.
- Analysis of the distribution and function of mast cells in different tissues.
- Correlation of mast cell population and activity changes with aging and disease development.
Main Results:
- Mast cells are crucial regulators of physiological processes in tissues where they are present.
- Changes in mast cell numbers and activity are observed during aging.
- Altered mast cell function is linked to age-related skin and mucous membrane changes.
- Mast cell involvement is associated with central nervous system disorders, including neurodegenerative diseases and mood disorders.
Conclusions:
- Mast cells play a significant role in tissue homeostasis and physiological regulation.
- Age-related alterations in mast cells contribute to the pathophysiology of various age-associated conditions.
- Further research into mast cell modulation may offer therapeutic strategies for age-related diseases and neurological disorders.
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