[Immunity, aging and works of V.M.Dilman.]
A V Polevshchikov1, P G Nazarov1
1Institute of Experimental Medicine, 12 Acad. Pavlov str., St. Petersburg, 197376, Russian Federation,
Advances in Gerontology = Uspekhi Gerontologii
|February 7, 2021
Summary
This review explores Vladimir M. Dilman's aging concept, focusing on immunocooperative interactions and T-cell functions. It examines age-related immunity changes and the inflammaging theory through Dilman's perspective.
Area of Science:
- Gerontology
- Immunology
- Endocrinology
- Oncology
Background:
- The review honors gerontologist Vladimir M. Dilman's contributions.
- Dilman's concept of aging prominently features immunocooperative interactions.
- Aging is associated with significant changes in the immune system.
Purpose of the Study:
- To provide a historical analysis of immunocooperative interaction hypotheses.
- To review the history and functions of T-cell populations in aging.
- To examine the inflammaging theory in the context of Dilman's aging concept.
Main Methods:
- Historical analysis of scientific literature.
- Review of T-cell populations and sub-populations.
- Comparative analysis of aging theories.
Main Results:
- Immunocooperative interactions are central to Dilman's aging theory.
- Age-specific changes in T-cell immunity are significant.
- The inflammaging theory aligns with Dilman's concept.
Conclusions:
- Dilman's work provides a foundational framework for understanding aging and immunity.
- Further research into T-cell dynamics is crucial for gerontology.
- Integrating immunocooperative interactions and inflammaging offers insights into aging processes.
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