Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Gonadal and Placental Hormones01:24

Gonadal and Placental Hormones

3.5K
The gonads, namely the testes in males and the ovaries in females, are pivotal in producing gonadal hormones that orchestrate the intricate processes of sexual development and reproduction.
In males, testosterone is the primary gonadal androgen. It plays a central role in the maturation of male reproductive organs — the penis and testes. Additionally, testosterone is instrumental in the development of secondary sexual characteristics — a deep voice as well as facial and pubic hair...
3.5K
Major Hormones and Their Functions01:27

Major Hormones and Their Functions

2.2K
Hormones, the biochemical messengers produced by endocrine glands, are pivotal in regulating bodily functions and maintaining homeostasis. Each hormone's balance is crucial; imbalances can lead to significant physiological disruptions. Major hormones include oxytocin, cortisol, epinephrine, estrogen, testosterone, thyroxine, growth hormone, insulin, and glucagon.
Oxytocin, produced in the hypothalamus and released by the pituitary gland, plays a role in social bonding, childbirth, and...
2.2K
Testosterone: Functions and Regulation01:26

Testosterone: Functions and Regulation

2.6K
The intricate hormonal interplay essential for male reproductive health begins with the release of gonadotropin-releasing hormone (GnRH) by the hypothalamus. This hormone prompts the pituitary gland to secrete follicle-stimulating hormone (FSH) and luteinizing hormone (LH). LH targets the Leydig cells in the testes, stimulating them to produce and release testosterone. In concert with testosterone, FSH acts on the Sertoli cells within the seminiferous tubules to facilitate the release of...
2.6K
Signs of Puberty01:27

Signs of Puberty

1.7K
Puberty is a critical phase, typically beginning between the ages of 8 and 13 in girls and 9 and 14 in boys, though timing can vary based on genetics, environmental factors, and overall health. This period is characterized by the development of secondary sexual characteristics and the attainment of reproductive potential. Endocrine changes underpin puberty, with hormonal surges of Luteinizing Hormone (LH) and Follicle-Stimulating Hormone (FSH) instigated by Gonadotropin-Releasing Hormone (GnRH)...
1.7K
Menopause01:28

Menopause

5.1K
Menopause, a natural biological process marking the end of a woman's fertility, typically occurs between the fifth and sixth decade of life. This phase is characterized by the exhaustion of the ovarian follicle pool, leading to less responsive ovaries despite the high levels of Follicle Stimulating Hormone (FSH) and Luteinizing Hormone (LH). The consequential decrease in estrogen production results in symptoms like hot flashes, heavy sweating, headaches, hair loss, muscle pains, vaginal...
5.1K
Development of the Sexual Organs in the Embryo and Fetus01:15

Development of the Sexual Organs in the Embryo and Fetus

4.3K
Development of the reproductive organs in an embryo starts from a bipotential state. This means the early embryo can develop either male or female reproductive organs. The formation of these organs begins with the growth of gonadal ridges that arise from the intermediate mesoderm during the fifth week of development.
Near the gonadal ridges, two duct systems are present: the mesonephric ducts (Wolffian ducts) and paramesonephric ducts (Müllerian ducts). These ducts form the basis for the...
4.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Primary and motile cilia in the efferent ductules: a role for IFT88 in maintaining male fertility.

Cellular and molecular life sciences : CMLS·2026
Same author

Corrigendum to: Influence of neonatal estrogens on rat prostate development.

Reproduction, fertility, and development·2026
Same author

Estrogen Receptor Expression in GnRH Neurons: Back to the Future.

Biology of reproduction·2026
Same author

2-Deoxyglucose dendrimer-enabled niclosamide delivery to FRβ-expressing macrophages alleviates endometriosis progression and associated hyperalgesia.

bioRxiv : the preprint server for biology·2026
Same author

Polychlorinated biphenyl 153 alters the intestinal epithelial cell transcriptome.

Biomedical reports·2026
Same author

A hidden protamine PTM code in sperm generates heterogeneous chromatin states and finetunes reproductive fitness.

bioRxiv : the preprint server for biology·2025

Related Experiment Video

Updated: Mar 1, 2026

Establishment of Rat Models Mimicking Gender-affirming Hormone Therapies
06:24

Establishment of Rat Models Mimicking Gender-affirming Hormone Therapies

Published on: January 10, 2025

1.6K

Estrogens in Male Physiology.

Paul S Cooke1, Manjunatha K Nanjappa1, CheMyong Ko1

  • 1Department of Physiological Sciences, University of Florida, Gainesville, Florida; Department of Comparative Biosciences, University of Illinois at Urbana-Champaign, Urbana, Illinois; Department of Urology, College of Medicine, University of Illinois at Chicago, Chicago, Illinois.

Physiological Reviews
|May 26, 2017
PubMed
Summary
This summary is machine-generated.

Estrogens, including 17β-estradiol (E2), are crucial for male reproductive and nonreproductive organ function. Estrogen signaling through estrogen receptors (ESR1, ESR2) and GPER impacts male fertility and overall health.

More Related Videos

An In Vivo Estrogen Deficiency Mouse Model for Screening Exogenous Estrogen Treatments of Cardiovascular Dysfunction After Menopause
06:18

An In Vivo Estrogen Deficiency Mouse Model for Screening Exogenous Estrogen Treatments of Cardiovascular Dysfunction After Menopause

Published on: August 13, 2019

13.0K
Prospecting Microbial Strains for Bioremediation and Probiotics Development for Metaorganism Research and Preservation
09:49

Prospecting Microbial Strains for Bioremediation and Probiotics Development for Metaorganism Research and Preservation

Published on: October 31, 2019

23.3K

Related Experiment Videos

Last Updated: Mar 1, 2026

Establishment of Rat Models Mimicking Gender-affirming Hormone Therapies
06:24

Establishment of Rat Models Mimicking Gender-affirming Hormone Therapies

Published on: January 10, 2025

1.6K
An In Vivo Estrogen Deficiency Mouse Model for Screening Exogenous Estrogen Treatments of Cardiovascular Dysfunction After Menopause
06:18

An In Vivo Estrogen Deficiency Mouse Model for Screening Exogenous Estrogen Treatments of Cardiovascular Dysfunction After Menopause

Published on: August 13, 2019

13.0K
Prospecting Microbial Strains for Bioremediation and Probiotics Development for Metaorganism Research and Preservation
09:49

Prospecting Microbial Strains for Bioremediation and Probiotics Development for Metaorganism Research and Preservation

Published on: October 31, 2019

23.3K

Area of Science:

  • Endocrinology
  • Reproductive Biology
  • Molecular Biology

Background:

  • Estrogens historically linked to female reproduction.
  • Estrogens and their receptors (ESR1, ESR2, GPER) also regulate male organs.
  • 17β-estradiol (E2) is present in male circulation and reproductive tract fluids.

Purpose of the Study:

  • To review the established and emerging roles of estrogens in male physiology.
  • To highlight the impact of estrogen signaling on male reproductive and nonreproductive functions.
  • To underscore the importance of estrogen signaling in male health.

Main Methods:

  • Review of existing literature on estrogen signaling in males.
  • Analysis of studies involving estrogen receptor expression and function in male tissues.
  • Examination of data from animal models and human studies on estrogen exposure and signaling disruption.

Main Results:

  • Estrogen receptors ESR1 and ESR2, and GPER are expressed in various male tissues.
  • Estrogen signaling is vital for efferent ductule and epididymal function, impacting sperm quality.
  • Loss of estrogen signaling affects nonreproductive tissues including brain, bone, and cardiovascular system.

Conclusions:

  • Estrogens are significant physiological regulators in males.
  • Estrogen signaling pathways are critical for both male reproduction and systemic health.
  • Further research is needed to fully elucidate the diverse roles of estrogen signaling in males.