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Author Spotlight: Advancing Research on Candida albicans Biofilm-Associated Prosthetic Joint Infections
Published on: February 2, 2024
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Brucella melitensis prosthetic joint infection
Domenica Flury1, Henrik Behrend2, Parham Sendi3
1Department of Infectious Diseases, Cantonal Hospital of St. Gallen, St. Gallen.
Journal of Bone and Joint Infection
|May 26, 2017
Summary
Brucella periprosthetic joint infection (PJI) is rare but challenging to diagnose, especially outside endemic areas. Prompt diagnosis and antimicrobial treatment, often combined, lead to successful outcomes in most Brucella PJI cases.
Area of Science:
- Infectious Diseases
- Orthopedic Surgery
- Microbiology
Background:
- Periprosthetic joint infection (PJI) caused by Brucella species is uncommon.
- Diagnosis can be difficult, particularly in regions where Brucella is not endemic.
- This study reviews a case and existing literature on Brucella PJI.
Purpose of the Study:
- To highlight the diagnostic challenges of Brucella PJI.
- To review current management strategies and outcomes.
- To provide guidance for clinicians managing suspected Brucella PJI.
Main Methods:
- Case report of a 75-year-old male with Brucella PJI.
- Comprehensive literature search for additional Brucella PJI cases.
- Analysis of diagnostic approaches, treatment modalities, and patient outcomes.
Main Results:
- Brucella PJI diagnosis is challenging, necessitating serological tests before invasive procedures.
- Infection control and laboratory communication are crucial.
- No standardized treatment exists for surgical intervention or antimicrobial duration.
- Most cases achieve successful outcomes with combination antimicrobial therapy for ≥12 weeks.
Conclusions:
- Early serological screening is recommended for suspected Brucella PJI, especially in non-endemic areas.
- Multidisciplinary collaboration is essential for effective management.
- Successful outcomes are achievable with appropriate antimicrobial regimens, regardless of surgical approach.
