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Updated: Mar 1, 2026
Author Spotlight: Advancing Research on Candida albicans Biofilm-Associated Prosthetic Joint Infections
Published on: February 2, 2024
Brucella melitensis prosthetic joint infection
Domenica Flury1, Henrik Behrend2, Parham Sendi3
1Department of Infectious Diseases, Cantonal Hospital of St. Gallen, St. Gallen.
Abstract:
Periprosthetic joint infection (PJI) due to Brucella spp. is rare. We report a case in a 75-year-old man and review 29 additional cases identified in a literature search. The diagnosis of Brucella PJI is challenging, in particular in non-endemic countries. Serological tests prior to joint aspiration or surgical intervention are reasonable. Involvement of infection control and timely information to laboratory personnel is mandatory upon diagnosis. There is no uniform treatment concept, neither with respect to surgical intervention nor for the duration of antimicrobials. Most cases have a successful outcome, irrespective of surgical modality, and with an antimicrobial combination regimen for 12 or more weeks.
Insights
Brucella periprosthetic joint infection (PJI) is rare but challenging to diagnose, especially outside endemic areas. Prompt diagnosis and antimicrobial treatment, often combined, lead to successful outcomes in most Brucella PJI cases.
Area of Science:
- Infectious Diseases
- Orthopedic Surgery
- Microbiology
Background:
- Periprosthetic joint infection (PJI) caused by Brucella species is uncommon.
- Diagnosis can be difficult, particularly in regions where Brucella is not endemic.
- This study reviews a case and existing literature on Brucella PJI.
Purpose of the Study:
- To highlight the diagnostic challenges of Brucella PJI.
- To review current management strategies and outcomes.
- To provide guidance for clinicians managing suspected Brucella PJI.
Main Methods:
- Case report of a 75-year-old male with Brucella PJI.
- Comprehensive literature search for additional Brucella PJI cases.
- Analysis of diagnostic approaches, treatment modalities, and patient outcomes.
Main Results:
- Brucella PJI diagnosis is challenging, necessitating serological tests before invasive procedures.
- Infection control and laboratory communication are crucial.
- No standardized treatment exists for surgical intervention or antimicrobial duration.
- Most cases achieve successful outcomes with combination antimicrobial therapy for ≥12 weeks.
Conclusions:
- Early serological screening is recommended for suspected Brucella PJI, especially in non-endemic areas.
- Multidisciplinary collaboration is essential for effective management.
- Successful outcomes are achievable with appropriate antimicrobial regimens, regardless of surgical approach.
