Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Magnetic Resonance Imaging

Magnetic Resonance Imaging

Magnetic resonance imaging (MRI) is a noninvasive medical imaging technique based on a phenomenon of nuclear physics discovered in the 1930s, in which matter exposed to magnetic fields and radio waves was found to emit radio signals. In 1970, a physician and researcher named Raymond Damadian noticed that malignant (cancerous) tissue gave off different signals than normal body tissue. He applied for a patent for the first MRI scanning device in clinical use by the early 1980s. The early MRI...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Microelectrode arrays enable directional stereo-EEG during kainate-mediated seizures.

bioRxiv : the preprint server for biology·2026

Same author

An evaluation of brain volume and cortical thickness measurement at 0.55 T.

Magma (New York, N.Y.)·2026

Same author

Screening for Normal Pressure Hydrocephalus on Head CT Using Automated Callosal Angle Assessment.

Tomography (Ann Arbor, Mich.)·2026

Same author

Conversion of 3 T liver, spleen, pancreas, and kidney R2* measurements to 1.5 T R2* equivalents: Validation of a theoretical framework.

Magnetic resonance imaging·2026

Same author

Bulk Flow of Cerebrospinal Fluid in the Cervicothoracic Spine.

AJNR. American journal of neuroradiology·2026

Same author

Variability in the circulation of cerebrospinal fluid: causes and clinical implications for intraventricular drug delivery.

Frontiers in drug delivery·2026

Same journal

Diffusion MRI of white matter alterations in chronic traumatic brain injury: a systematic review and meta-analysis.

NeuroImage. Clinical·2026

Same journal

Decoding functional changes in the brain following ischemic stroke: a multimodal feature approach integrating fNIRS with machine learning and deep learning.

NeuroImage. Clinical·2026

Same journal

Structural brain alterations in chronic primary pain: a multimodal MRI study.

NeuroImage. Clinical·2026

Same journal

Using functional MRI neurofeedback to modulate self-blame in major depressive disorder: A pilot study.

NeuroImage. Clinical·2026

Same journal

Language network reorganization in temporal lobe epilepsy: insights from task-based functional MRI.

NeuroImage. Clinical·2026

Same journal

Functional brain biomarkers of self-referential bias in remitted depressed outpatients: a randomized controlled trial.

NeuroImage. Clinical·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Mar 1, 2026

Magnetic Levitation Coupled with Portable Imaging and Analysis for Disease Diagnostics

Magnetic Levitation Coupled with Portable Imaging and Analysis for Disease Diagnostics

Published on: February 19, 2017

Hemoglobin and mean platelet volume predicts diffuse T1-MRI white matter volume decrease in sickle cell disease

Soyoung Choi¹, Adam M Bush², Matthew T Borzage³

¹Neuroscience Graduate Program, University of Southern California, 3641 Watt Way, HNB 120, Los Angeles, CA 90089-2520, USA; Signal and Image Processing Institution, University of Southern California, 3740 McClintock Avenue, EEB 400, Los Angeles, CA 90089-2560, USA; Department of Pediatrics and Radiology, Children's Hospital Los Angeles USC, 4650 Sunset Blvd., MS #81, Los Angeles, CA 90027, USA.

Neuroimage. Clinical

|May 26, 2017

Summary

This summary is machine-generated.

Sickle cell disease (SCD) causes significant white matter volume reduction in young adults. Lower brain white matter in SCD patients is linked to hemoglobin levels and mean platelet volume, suggesting microvascular damage.

Keywords:

ACA, anterior cerebral artery GM, grey matter Hemoglobin HgB, hemoglobin MCA, middle cerebral artery MPV, mean platelet volume MRI, magnetic resonance imaging Mean platelet volume PCA, posterior cerebral artery ROI, region of interest SCD, sickle cell disease Sickle cell disease Structural MRI WM, white matter WMHI, white matter hyperintensities White matter

More Related Videos

A Precision Medicine Tool for Measurement and Monitoring of Hemoglobin S in Sickle Cell Disease Patients Receiving Transfusion Therapy

A Precision Medicine Tool for Measurement and Monitoring of Hemoglobin S in Sickle Cell Disease Patients Receiving Transfusion Therapy

Characterization of Sickling During Controlled Automated Deoxygenation with Oxygen Gradient Ektacytometry

Characterization of Sickling During Controlled Automated Deoxygenation with Oxygen Gradient Ektacytometry

Published on: November 5, 2019

Related Experiment Videos

Last Updated: Mar 1, 2026

Magnetic Levitation Coupled with Portable Imaging and Analysis for Disease Diagnostics

Magnetic Levitation Coupled with Portable Imaging and Analysis for Disease Diagnostics

Published on: February 19, 2017

A Precision Medicine Tool for Measurement and Monitoring of Hemoglobin S in Sickle Cell Disease Patients Receiving Transfusion Therapy

A Precision Medicine Tool for Measurement and Monitoring of Hemoglobin S in Sickle Cell Disease Patients Receiving Transfusion Therapy

Characterization of Sickling During Controlled Automated Deoxygenation with Oxygen Gradient Ektacytometry

Characterization of Sickling During Controlled Automated Deoxygenation with Oxygen Gradient Ektacytometry

Published on: November 5, 2019

Area of Science:

Neurology
Radiology
Genetics

Background:

Sickle cell disease (SCD) is a genetic disorder causing chronic vascular complications and neurological damage.
Limited research quantifies SCD's impact on brain morphometry, especially in older patients.

Purpose of the Study:

To quantify global and regional brain volumes in adolescent and young adult SCD patients.
To differentiate SCD-related brain changes from normal maturation.
To identify factors associated with brain morphometry in SCD.

Main Methods:

T1-weighted MRI scans were acquired from 33 SCD patients and 32 controls.
Brain volumes were compared, correcting for age and sex.
Multivariate analysis identified predictors of white matter volume.

Main Results:

SCD patients showed significantly lower white matter volume (8.1% right, 6.8% left hemisphere) compared to controls.
Hemoglobin, sex, and mean platelet volume were significant predictors of white matter volume.
Reduced white matter volume was observed in anterior and middle cerebral artery territories, particularly frontal, parietal, and temporal lobes.

Conclusions:

SCD is associated with diffuse white matter abnormalities, especially in younger brain regions.
Chronic microvascular insufficiency and hypoxia are likely mechanisms.
Longitudinal studies are needed to further elucidate SCD's brain pathophysiology.