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Updated: Mar 1, 2026

A Microwave-Assisted Direct Heteroarylation of Ketones Using Transition Metal Catalysis
Published on: February 16, 2020
Recent advances in N-heterocyclic carbene catalyzed achiral synthesis
Qiao Ren1, Muyao Li1, Lujiang Yuan1
1College of Pharmaceutical Science, Southwest University, Chongqing 400715, China. qren2014@swu.edu.cn.
Abstract:
N-Heterocyclic carbenes (NHCs) have emerged as powerful and elegant organocatalysts in a variety of newly developed and unprecedented enantioselective transformations due to their unique umpolung capacity. As a supplement to conventional enantioselective organocatalysis, NHC-induced non-asymmetric catalysis has gradually attracted much interest in recent years. Herein, this review aims to reveal the recent developments in NHC-promoted non-asymmetric umpolung transformations resulting in the expeditious construction of versatile achiral natural heterocycles, carbocycles and acylated products.
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