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Updated: May 15, 2026

Efficient Synthesis of All-Carbon Quaternary Centers via the Conjugate Addition of Functionalized Monoorganozinc Bromides
Published on: May 26, 2019
Assembly of Chiral Helical Quinones via Enantioselective Organocatalytic [4+2] Annulation
Shujie Ji1, Jie Yu1, Jian Wang1
1School of Pharmaceutical Sciences, Key Laboratory of Bioorganic Phosphorous Chemistry and Chemical Biology (Ministry of Education), Tsinghua University, Beijing 100084, China.
Abstract:
Chiral helicenes are widely found in materials science, self-assembly, and asymmetric catalysis, yet their asymmetric construction remains highly challenging. Herein, we report an unprecedented asymmetric synthesis of helical quinones via an enantioselective amine-catalyzed [4+2] annulation. This method features a broad substrate scope, excellent functional group tolerance, and moderate to good yields with high enantioselectivities, providing a new strategy for the construction of chiral helicenes.
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