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Updated: Mar 1, 2026

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache
Published on: June 2, 2014
Aura and Other Neurologic Dysfunction in or with Migraine
Narayan R Kissoon1, Fred Michael Cutrer1
1Division of Headache, Department of Neurology, Mayo Clinic, Rochester, MN, USA .
Premise:
Migraine can present with a wide range of neurological symptoms.
Problem:
Based on currently available data, the symptoms of typical migraine aura are most likely related to cortical spreading depression (CSD), and evidence supports that CSD can lead to trigeminovascular activation resulting in the headache phase of migraine.
Potential Solution:
An alternative diagnosis to migraine aura should be considered if migrainous headaches present with transient neurological symptoms that have features inconsistent with aura.
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