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Related Concept Videos

Asthma-III: Symptoms and Complications01:24

Asthma-III: Symptoms and Complications

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Asthma, a common chronic respiratory condition, is classified considering the frequency and severity of symptoms alongside lung function impairment. Understanding this classification is essential for appropriate treatment and management. Here's a detailed look at the classification of asthma and its clinical features and complications:
Classification of Asthma
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Asthma-IV: Diagnostic and Management01:30

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The diagnosis and management of asthma are comprehensive, encompassing clinical assessments, lung function tests, and pharmacological interventions. Here's an overview:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
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Asthma-I: Introduction01:29

Asthma-I: Introduction

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Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
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Asthma-II: Pathophysiology and Classification01:26

Asthma-II: Pathophysiology and Classification

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Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
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Asthma: Pathogenesis and Management01:20

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Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
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Antiasthma Drugs: Leukotriene Modifiers01:19

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Leukotriene modifiers, or cysteinyl leukotriene receptor antagonists, are medications used to manage chronic asthma. These agents target specific inflammatory mediators produced during arachidonic acid metabolism, an essential process in generating inflammation in the body.
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Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma
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Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma

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Severe asthma in children.

Andrew Bush1, Louise Fleming1, Sejal Saglani1

  • 1Paediatric Respiratory Medicine, National Heart and Lung Institute, Imperial College and Royal Brompton Harefield NHS Foundation Trust, London, UK.

Respirology (Carlton, Vic.)
|May 26, 2017
PubMed
Summary
This summary is machine-generated.

Severe pediatric asthma requires a comprehensive assessment beyond treatment levels. New approaches reveal unique mechanisms, differing significantly from adult severe asthma, emphasizing tailored management for children.

Keywords:
adherenceexercise-induced laryngeal obstructioninnate lymphoid cellobesitysteroid resistance

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Area of Science:

  • Pediatric Pulmonology
  • Immunology
  • Asthma Research

Background:

  • Most childhood asthma is controlled with inhaled corticosteroids (ICSs).
  • Problematic severe asthma in children may be undertreated or misdiagnosed.
  • Current definitions of severe asthma are too narrow, especially for pediatric cases.

Purpose of the Study:

  • To reassess the classification and management of difficult and severe therapy-resistant asthma in children.
  • To investigate novel multidomain approaches for diagnosing steroid resistance in pediatric severe asthma.
  • To explore underlying mechanisms differentiating pediatric severe asthma from adult forms.

Main Methods:

  • Confirmation of asthma diagnosis and assessment of co-morbidities.
  • Nurse-led assessment to characterize asthma severity.
  • Bronchoscopy and intramuscular steroid injection to determine steroid resistance.

Main Results:

  • A dichotomous classification of difficult vs. severe therapy-resistant asthma may need reconsideration.
  • Novel mechanistic insights include the absence of T-helper 2 (TH2) cytokines in some eosinophilic severe asthma.
  • Potential roles for IL-33 and innate lymphoid cells, and association of intraepithelial neutrophils with better outcomes were identified.

Conclusions:

  • Severe pediatric asthma is distinct from adult severe asthma and requires specialized approaches.
  • Multidomain assessment is crucial for accurate diagnosis and management of pediatric severe asthma.
  • Understanding unique pediatric asthma mechanisms is vital for effective treatment strategies.