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Related Experiment Video

Updated: Mar 1, 2026

Orthotopic Transplantation of Breast Tumors as Preclinical Models for Breast Cancer
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Breast Cancer and Transplantation.

G Wong1,2, E Au1, S V Badve3

  • 1Centre for Transplant and Renal Research, Westmead Hospital, Westmead, NSW, Australia.

American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons
|May 26, 2017
PubMed
Summary

Breast cancer outcomes are poor in solid organ transplant recipients, despite similar incidence to the general population. Early detection and targeted interventions are crucial for improving survival in this vulnerable group.

Keywords:
cancer/malignancy/neoplasia: adjuvant therapycancer/malignancy/neoplasia: chemotherapycancer/malignancy/neoplasia: metastatic diseasecancer/malignancy/neoplasia: registry/incidencecancer/malignancy/neoplasia: risk factorsclinical research/practicehealth services and outcomes researchorgan transplantation in general

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Area of Science:

  • Oncology
  • Transplantation Medicine
  • Cancer Epidemiology

Background:

  • Breast cancer poses significant challenges for solid organ transplant recipients.
  • While incidence is comparable to the general population, outcomes are poorer.
  • Current cancer screening guidelines are based on general population recommendations and are not well-studied in transplant recipients.

Purpose of the Study:

  • To review the epidemiology of breast cancer in solid organ transplant recipients.
  • To discuss screening and preventive strategies for at-risk individuals.
  • To explore novel genomic profiling and targeted interventions for post-transplant breast cancer.

Main Methods:

  • Literature review focusing on breast cancer in solid organ transplant recipients.
  • Analysis of epidemiological data and clinical outcomes.
  • Examination of current and emerging screening, diagnostic, and therapeutic strategies.

Main Results:

  • Solid organ transplant recipients with breast cancer experience poorer outcomes compared to the general population.
  • Disease recurrence after transplantation is rare but associated with high mortality.
  • Limited data exists on the efficacy of cancer screening interventions in this population.

Conclusions:

  • There is a critical need for tailored breast cancer screening and management strategies for solid organ transplant recipients.
  • Genomic profiling and targeted therapies offer potential for improved outcomes.
  • Further research is essential to optimize early detection and treatment protocols.