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Updated: Mar 1, 2026

Detrusor Underactivity Model in Rats by Conus Medullaris Transection
Published on: August 28, 2020
[Pathophysiology of detrusor underactivity in the elderly]
J Kerdraon1, B Peyronnet2, X Gamé3
1Centre mutualiste de rééducation et réadaptation Kerpape, BP 78, 56275 Ploemeur cedex, France.
Detrusor underactivity in the elderly is linked to aging-related myogenic and neurogenic dysfunctions. Comorbidities like diabetes and bladder outlet obstruction further contribute to this condition, impacting lower urinary tract function.
Area of Science:
- Gerontology
- Urology
- Pathophysiology
Background:
- Detrusor underactivity (DU) is a common condition in the elderly, affecting bladder function.
- Its prevalence varies widely (8-48%) based on definition and population studied.
- Understanding DU pathophysiology is crucial for effective management in aging populations.
Purpose of the Study:
- To review existing evidence on the pathophysiology of detrusor underactivity in the elderly.
- To synthesize current knowledge on age-related and comorbidity-driven factors contributing to DU.
Main Methods:
- A comprehensive literature review was performed.
- Searches were conducted in July 2016 using Medline/Pubmed.
- The review included studies published in English or French.
Main Results:
- Aging itself contributes to DU via myogenic (detrusor muscle degeneration) and neurogenic (innervation changes) dysfunctions.
- Comorbidities prevalent in the elderly, such as diabetes, bladder outlet obstruction, and estrogen deficiency, are implicated.
- Detrusor overactivity may coexist or be related to DU, suggesting a common underlying lower urinary tract issue.
Conclusions:
- The pathophysiology of detrusor underactivity in the elderly is complex and not fully understood.
- Myogenic and neurogenic factors associated with aging are key contributors.
- Numerous age-related comorbidities significantly influence the development and presentation of DU.
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