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Aqueous proinflammatory cytokines in acute primary angle-closure eyes
Yao-Ming Liu1, Shi-Da Chen1, Xing-Yi Li1
1Zhongshan Ophthalmic Center, State Key Laboratory of Ophthalmology, Sun Yat-sen University, Guangzhou 510060, Guangdong Province, China.
International Journal of Ophthalmology
|May 27, 2017
Summary
Elevated levels of interleukin-12, -15, -6, and -27 were found in the aqueous humor of patients with acute primary angle-closure (APAC) glaucoma, suggesting their role in the disease pathology.
Area of Science:
- Ophthalmology
- Immunology
- Glaucoma Research
Background:
- Acute primary angle-closure (APAC) is a severe form of glaucoma.
- The role of intraocular inflammation in APAC pathogenesis is not fully understood.
Purpose of the Study:
- To compare proinflammatory cytokine levels in aqueous humor between APAC patients and age-related cataract patients.
- To investigate potential correlations between cytokine levels and clinical factors in APAC.
Main Methods:
- A cross-sectional study involving 20 APAC eyes and 15 age-related cataract eyes.
- Aqueous humor samples were analyzed for 20 proinflammatory cytokines using multiplex bead immunoassay.
- Clinical data were collected for correlation analysis.
Main Results:
- Interleukin (IL)-12, IL-15, IL-6, and IL-27 were significantly elevated in APAC eyes compared to cataract eyes.
- IL-27 was exclusively detected in APAC eyes.
- Elevated IL-12 and IL-6 correlated with patient age; IL-15, IL-27, and TNF-α correlated with time since APAC onset.
Conclusions:
- Specific proinflammatory cytokines, including IL-12, IL-15, IL-6, and IL-27, are elevated in APAC.
- These cytokines may play a significant role in the pathological mechanisms of acute primary angle-closure glaucoma.
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