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Related Experiment Videos

Drugging the pain epigenome.

Ellen Niederberger1, Eduard Resch2, Michael J Parnham2

  • 1Pharmazentrum Frankfurt, Zentrum für Arzneimittelforschung Entwicklung und Sicherheit (ZAFES), Institut für Klinische Pharmakologie, Klinikum der Goethe-Universität Frankfurt, Theodor Stern Kai 7, 60590 Frankfurt am Main, Germany.

Nature Reviews. Neurology
|May 27, 2017
PubMed
Summary
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Epigenetic mechanisms influence chronic pain. Modulating these mechanisms, like DNA methylation and microRNAs (miRNAs), shows promise for novel pain relief, but challenges remain for clinical use.

Area of Science:

  • Pain research
  • Epigenetics
  • Pharmacology

Background:

  • Chronic pain affects over 20% of adults globally, often leading to comorbidities and reduced quality of life.
  • Current analgesics have limitations in efficacy and safety, necessitating new therapeutic strategies.
  • Epigenetic mechanisms, including DNA methylation, histone modifications, and microRNAs (miRNAs), are implicated in the pathophysiology of chronic pain.

Purpose of the Study:

  • To review the role of epigenetic mechanisms in chronic pain.
  • To critically assess the potential of epigenetic modulation as a therapeutic strategy for pain management.
  • To highlight challenges and novel approaches in developing epigenetic drugs for pain.

Main Methods:

  • Review of existing scientific literature on epigenetics and pain.

Related Experiment Videos

  • Analysis of studies investigating epigenetic modulators in animal models of pain.
  • Critical evaluation of clinical development challenges for epigenetic analgesics.

    • Main Results:

    • Epigenetic mechanisms significantly regulate gene expression relevant to pain.
    • Inhibitors and modulators of epigenetic processes have shown potential in reversing pain-associated epigenetic changes in preclinical studies.
    • Epigenetic modulation may reduce nociception and offer new avenues for chronic pain treatment.

    Conclusions:

    • Epigenetic modulation presents a promising frontier for developing novel analgesics for chronic pain.
    • Overcoming challenges such as nonspecific effects and targeted delivery is crucial for clinical translation.
    • Further research into new approaches for drug modulation of the pain epigenome is warranted.